SCHEMBL7516234

SCHEMBL7516234

CCCCCc1cnc(-c2ccc(F)c(F)c2)nc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 8/20 0.56
RAB9A P51151 7/20 0.52
SMN1; SMN2 Q16637 6/20 0.52
MAPT P10636 3/20 0.52
HSD17B10 Q99714 3/20 0.52
KDM4E B2RXH2 1/20 0.52
MEN1 O00255 1/20 0.52
USP2 O75604 1/20 0.52
ALDH1A1 P00352 1/20 0.52
GAA P10253 1/20 0.52
HPGD P15428 1/20 0.52
KMT2A Q03164 1/20 0.52
RARA P10276 1/20 0.45
RARG P13631 1/20 0.45
GCGR P47871 1/20 0.44
NPC1 O15118 5/20 0.44
NFKB1 P19838 2/20 0.44
NFKB2 Q00653 2/20 0.44
RELA Q04206 2/20 0.44
STAT3 P40763 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10731135 0.98 RARB (0.58) RARBRAB9ASMN1; SMN2MAPTHSD17B10
SCHEMBL10733402 0.98 RARB (0.58) RARBRAB9ASMN1; SMN2MAPTHSD17B10
SCHEMBL10728895 0.95 RARB (0.50) RARBRAB9ASMN1; SMN2MAPTHSD17B10
SCHEMBL15783706 0.94 RARB (0.57) RARBRAB9ASMN1; SMN2MAPTHSD17B10
SCHEMBL8380866 0.93 RARB (0.59) RARBRAB9ASMN1; SMN2MAPTHSD17B10
SCHEMBL7519352 0.89 RAB9A (0.51) RARBRAB9ASMN1; SMN2MAPTHSD17B10
SCHEMBL9399554 0.88 RARB (0.53) RARBRAB9ASMN1; SMN2MAPTHSD17B10
SCHEMBL10606342 0.87 RARB (0.56) RARBRAB9ASMN1; SMN2MAPTHSD17B10
SCHEMBL10560949 0.87 RARB (0.56) RARBRAB9ASMN1; SMN2MAPTHSD17B10
SCHEMBL10557647 0.87 RARB (0.56) RARBRAB9ASMN1; SMN2MAPTHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4640795-A REDUCED OPERATING VOLTAGE CHISSO CORPORATION (JP) 1987-02-03 US claimed
US-7198827-B1 Nematic liquid crystal composition and liquid crystal display device using the same DAINIPPON INK AND CHEMICALS, INC. (JP) 2007-04-03 US disclosed
EP-0742275-B1 LIQUID CRYSTAL COMPOUND AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME CHISSO CORP (JP) 2002-03-20 EP disclosed
EP-0640578-B2 Novel liquid crystalline compound having a 1,1,2,3,3,3,-hexafluoropropyl group and liquid crystal composition CHISSO CORP (JP) 2001-06-27 EP disclosed
EP-0727473-B1 Liquid crystaline alkynyltolan compound, liquid crystal composition and liquid crystal display element CHISSO CORP (JP) 2000-01-12 EP disclosed
EP-0672742-B1 A hexenediyne derivative and a liquid crystal composition CHISSO CORP (JP) 1999-02-10 EP disclosed
EP-0688754-B1 DICYCLOHEXYLETHYLENE DERIVATIVE CHISSO CORP (JP) 1998-10-07 EP disclosed
US-5779936-A FLUORINATED BICYCLOHEXANE OR CYCLOHEXYLETHYL CYCLOHEXANE DERIVATIVE HAVING LOW VISCOSITY AND HIGH CLEARING POINT TEMPERATURE CHISSO CORPORATION (JP) 1998-07-14 US disclosed
EP-0640578-B1 Novel liquid crystalline compound having a 1,1,2,3,3,3,-hexafluoropropyl group and liquid crystal composition CHISSO CORP (JP) 1997-11-05 EP disclosed
EP-0597701-B1 Conjugated enyne derivative and liquid crystal composition CHISSO CORP (JP) 1997-04-16 EP disclosed
EP-0742275-A1 LIQUID CRYSTAL COMPOUND AND LIQUID CRYSTAL COMPOSITION CONTAINING THE SAME CHISSO CORPORATION (JP) 1996-11-13 EP disclosed
EP-0727473-A2 Liquid crystaline alkynyltolan compound, liquid crystal composition and liquid crystal display element Chisso Corporation (JP) 1996-08-21 EP disclosed
EP-0688754-A1 DICYCLOHEXYLETHYLENE DERIVATIVE CHISSO CORPORATION (JP) 1995-12-27 EP disclosed
EP-0672742-A1 A hexenediyne derivative and a liquid crystal composition CHISSO CORPORATION (JP) 1995-09-20 EP disclosed
EP-0640578-A1 Novel liquid crystalline compound having a 1,1,2,3,3,3,-hexafluoropropyl group and liquid crystal composition Chisso Corporation (JP) 1995-03-01 EP disclosed
EP-0597701-A1 Conjugated enyne derivative and liquid crystal composition CHISSO CORPORATION (JP) 1994-05-18 EP disclosed
US-4640795-A REDUCED OPERATING VOLTAGE CHISSO CORPORATION (JP) 1987-02-03 US disclosed