Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 4/20 | 0.44 |
| ▸ | GSK3B | P49841 | 4/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | RGS4 | P49798 | 2/20 | 0.40 |
| ▸ | RGS8 | P57771 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7512200 | 0.84 | KMT2A (0.47) | KMT2AHPGDCYP3A4GSK3AGSK3B | |
| SCHEMBL7466508 | 0.78 | HPGD (0.55) | KMT2AHPGDCYP3A4GSK3AGSK3B | |
| SCHEMBL14600369 | 0.77 | KMT2A (0.45) | KMT2AHPGDKDM4EMAPTMEN1 | |
| SCHEMBL5800712 | 0.76 | HPGD (0.49) | KMT2AHPGDCYP3A4GSK3AGSK3B | |
| SCHEMBL1584773 | 0.75 | HPGD (0.47) | KMT2AHPGDCYP3A4GSK3AGSK3B | |
| SCHEMBL7750738 | 0.75 | HPGD (0.51) | KMT2AHPGDCYP3A4GSK3AGSK3B | |
| SCHEMBL30272686 | 0.73 | HPGD (0.50) | KMT2AHPGDCYP3A4GSK3AGSK3B | |
| SCHEMBL8985073 | 0.72 | GSK3B (0.67) | KMT2AHPGDCYP3A4GSK3AGSK3B | |
| SCHEMBL19377760 | 0.71 | GSK3B (0.46) | KMT2ACYP3A4GSK3AGSK3BKDM4E | |
| SCHEMBL7521742 | 0.71 | HTT (0.45) | KMT2AHPGDKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107778254-A | The synthetic method of the pyrimidine derivatives of Internmediate of anti viral medicine oxo two | 陈国妃 | 2018-03-09 | — | — | CN | disclosed |
| CN-1352637-A | Process for preparing MKC-442 | TRIANGLE PHARMACEUTICALS INC (US) | 2002-06-05 | — | — | CN | disclosed |
| EP-1169310-A1 | PROCESS FOR PREPARING MKC-442 | Triangle Pharmaceuticals Inc. (US) | 2002-01-09 | — | — | EP | disclosed |
| EP-1169310-A1 | PROCESS FOR PREPARING MKC-442 | Triangle Pharmaceuticals Inc. (US) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000061566-A1 | PROCESS FOR PREPARING MKC-442 | TRIANGLE PHARMACEUTICALS, INC. (US) | 2000-10-19 | — | — | WO | disclosed |
| WO-2000061566-A1 | PROCESS FOR PREPARING MKC-442 | TRIANGLE PHARMACEUTICALS, INC. (US) | 2000-10-19 | — | — | WO | disclosed |