Sugi Predict

Sugi Predict / Compounds / SCHEMBL7519989

SCHEMBL7519989

SCHEMBL7519989

CC(C)(C)c1cc(-n2nc3ccccc3n2)c(O)c(C(C)(c2ccccc2)c2ccccc2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 4/20 0.45
▸ RAB9A P51151 4/20 0.45
▸ LMNA P02545 1/20 0.41
▸ POLB P06746 2/20 0.40
▸ CYP1A2 P05177 1/20 0.37
▸ CYP3A4 P08684 1/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37
▸ ESR1 P03372 2/20 0.36
▸ ESR2 Q92731 2/20 0.36
▸ PPARG P37231 1/20 0.34
▸ PPARA Q07869 1/20 0.34
▸ KDM4E B2RXH2 4/20 0.34
▸ HPGD P15428 2/20 0.34
▸ ALDH1A1 P00352 2/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ ALOX5 P09917 1/20 0.32
▸ PTGS2 P35354 1/20 0.32
▸ MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7523685 0.89 NPC1 (0.41) NPC1RAB9ALMNAPOLBCYP1A2
SCHEMBL1499910 0.89 NPC1 (0.45) NPC1RAB9ALMNAPOLBCYP1A2
SCHEMBL29708 0.89 NPC1 (0.49) NPC1RAB9ALMNAPOLBCYP1A2
SCHEMBL29350736 0.89 NPC1 (0.49) NPC1RAB9ALMNAPOLBCYP1A2
SCHEMBL7516817 0.88 HTT (0.45) NPC1RAB9ALMNAPOLBCYP3A4
SCHEMBL17011625 0.85 NPC1 (0.46) NPC1RAB9ALMNAPOLBCYP1A2
SCHEMBL5510301 0.85 NPC1 (0.41) NPC1RAB9ALMNAPOLBCYP1A2
SCHEMBL30393631 0.84 NPC1 (0.45) NPC1RAB9ALMNAPOLBCYP1A2
SCHEMBL6558920 0.84 NPC1 (0.45) NPC1RAB9ALMNAPOLBCYP1A2
SCHEMBL7521571 0.83 SMN1; SMN2 (0.38) NPC1RAB9ALMNAPOLBCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020169239-A1 2H-benzotriazole UV absorbers substituted with 1,1-diphenylakyl groups and compositions stabilized therewith WOOD MERVIN G (US) 2002-11-14 — — US claimed
US-6392056-B1 FOR THERMOPLASTIC RESINS CIBA SPECIALTY CHEMICAL CORPORATION 2002-05-21 — — US claimed
US-6489383-B1 SUCH AS 2-(2-HYDROXY-3-(1,1-DI(4-2-(BROMOETHOXY)PHENYL) ETHYL)-5-TERT-BUTYLPHENYL)-2H-BENZOTRIAZOLE FOR USE AS STOVING LACQUER, FINISHING ENAMEL FOR AUTOMOBILES CIBA SPECIALTY CHEMICALS CORPORATION 2002-12-03 — — US disclosed
US-20020169239-A1 2H-benzotriazole UV absorbers substituted with 1,1-diphenylakyl groups and compositions stabilized therewith WOOD MERVIN G (US) 2002-11-14 — — US disclosed
US-6392056-B1 FOR THERMOPLASTIC RESINS CIBA SPECIALTY CHEMICAL CORPORATION 2002-05-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020169239-A1 2H-benzotriazole UV absorbers substituted with 1,1-diphenylakyl groups and compositions stabilized therewith SUV39H1, SUV39H2, PAH NPC1 3986/4885RAB9A 4648/4885LMNA 3381/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.