Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 17/20 | 1.00 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.42 |
| ▸ | WNT3A | P56704 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7524387 | 0.96 | MTNR1A (1.00) | MTNR1AMTNR1BROCK2CYP3A4CYP2D6 | |
| SCHEMBL7526482 | 0.92 | MTNR1A (0.85) | MTNR1AMTNR1BROCK2CYP3A4CYP2D6 | |
| SCHEMBL7526968 | 0.85 | MTNR1A (0.73) | MTNR1AMTNR1B | |
| SCHEMBL6649870 | 0.83 | MTNR1A (0.71) | MTNR1AMTNR1BROCK2CYP3A4CYP2D6 | |
| SCHEMBL7527516 | 0.82 | MTNR1A (0.70) | MTNR1AMTNR1BCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7519831 | 0.81 | MTNR1A (0.67) | MTNR1AMTNR1BCYP2C9 | |
| SCHEMBL7520038 | 0.81 | MTNR1A (0.67) | MTNR1AMTNR1B | |
| SCHEMBL7517761 | 0.80 | MTNR1A (1.00) | MTNR1AMTNR1BCTNNB1WNT3A | |
| SCHEMBL7520573 | 0.80 | MTNR1A (0.73) | MTNR1AMTNR1B | |
| SCHEMBL7519028 | 0.79 | MTNR1A (0.65) | MTNR1AMTNR1BROCK2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873993-B1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-02-20 | — | — | EP | claimed |
| US-5919814-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 1999-07-06 | — | — | US | claimed |
| EP-0873993-A1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-10-28 | — | — | EP | claimed |
| EP-0873993-B1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-02-20 | — | — | EP | disclosed |
| EP-1064941-A1 | Use of melatoninergic ligands for obtaining pharmaceutical compositions for the prevention or the treatment of gastrointestinal pathologies | ADIR ET COMPAGNIE (FR) | 2001-01-03 | — | — | EP | disclosed |
| US-5919814-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 1999-07-06 | — | — | US | disclosed |
| EP-0873993-A1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-10-28 | — | — | EP | disclosed |