Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 15/20 | 0.85 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.47 |
| ▸ | WNT3A | P56704 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.44 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.42 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7520035 | 0.92 | MTNR1A (1.00) | MTNR1ACTNNB1WNT3AROCK2CYP3A4 | |
| SCHEMBL7524387 | 0.91 | MTNR1A (1.00) | MTNR1ACTNNB1WNT3AROCK2CYP3A4 | |
| SCHEMBL7519028 | 0.84 | MTNR1A (0.65) | MTNR1ACTNNB1WNT3AROCK2CYP3A4 | |
| SCHEMBL3430852 | 0.82 | MTNR1A (0.62) | MTNR1ACTNNB1WNT3AROCK2CYP3A4 | |
| SCHEMBL7517873 | 0.79 | MTNR1A (1.00) | MTNR1ACTNNB1WNT3AMTNR1B | |
| SCHEMBL7523790 | 0.79 | MTNR1A (0.86) | MTNR1ACTNNB1WNT3AMTNR1B | |
| SCHEMBL8481900 | 0.78 | MTNR1A (0.57) | MTNR1ACTNNB1WNT3AMTNR1B | |
| SCHEMBL1010497 | 0.77 | MTNR1A (1.00) | MTNR1AROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7526968 | 0.77 | MTNR1A (0.73) | MTNR1AMTNR1B | |
| SCHEMBL7520573 | 0.77 | MTNR1A (0.73) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873993-B1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-02-20 | — | — | EP | disclosed |
| US-5919814-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 1999-07-06 | — | — | US | disclosed |
| EP-0873993-A1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-10-28 | — | — | EP | disclosed |