Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7517901 | 0.89 | TDP1 (0.51) | TDP1MAPK10NFE2L2KMT2AMEN1 | |
| SCHEMBL7520091 | 0.82 | TDP1 (0.51) | TDP1NFE2L2GAAKMT2AMEN1 | |
| SCHEMBL7523674 | 0.79 | TDP1 (0.51) | TDP1MAPK10KMT2AMEN1RAB9A | |
| SCHEMBL7519789 | 0.77 | TDP1 (0.46) | TDP1NFE2L2KMT2AMEN1RAB9A | |
| SCHEMBL7518895 | 0.77 | TDP1 (0.46) | TDP1NFE2L2TSHRKMT2AMEN1 | |
| SCHEMBL7526105 | 0.74 | TDP1 (0.46) | TDP1NFE2L2KMT2AMEN1RAB9A | |
| SCHEMBL7521932 | 0.72 | TDP1 (0.71) | TDP1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL14611861 | 0.72 | TDP1 (0.71) | TDP1KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL2094929 | 0.72 | TSHR (0.59) | MAPK10TSHRJAK2P2RX7ERCC5 | |
| SCHEMBL16597732 | 0.70 | NPC1 (0.57) | NFE2L2GAAKMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0937044-B1 | CFTR CHANNEL ACTIVATOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | CENTRE NAT RECH SCIENT (FR) | 2002-01-30 | — | — | EP | disclosed |