Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.39 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ESRRA | P11474 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | SQLE | Q14534 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7517854 | 0.96 | ALOX15 (0.47) | ALOX15LMNATP53CYP3A4HPGD | |
| SCHEMBL7525650 | 0.87 | ALOX15 (0.44) | ALOX15LMNATP53CYP3A4HPGD | |
| SCHEMBL7516806 | 0.85 | ALOX15 (0.47) | ALOX15LMNATP53CYP3A4HPGD | |
| SCHEMBL7521656 | 0.83 | ALOX15 (0.45) | ALOX15LMNATP53CYP3A4HPGD | |
| Dimethylamine SCHEMBL7525639 | 0.82 | ESRRA (0.43) | ALOX15LMNAALDH1A1MAPTGAA | |
| SCHEMBL7520154 | 0.81 | ALOX15 (0.43) | ALOX15LMNATP53CYP3A4HPGD | |
| SCHEMBL7516405 | 0.80 | KDM4E (0.40) | LMNAHPGDALDH1A1KDM4ECYP1A2 | |
| Dimethylamine SCHEMBL7513266 | 0.79 | CA2 (0.41) | ALOX15MAPTGAASQLE | |
| SCHEMBL7515882 | 0.77 | ESRRA (0.45) | ALOX15LMNAALDH1A1MAPTGAA | |
| SCHEMBL5692389 | 0.74 | CA2 (0.45) | ALOX15CYP3A4ALDH1A1SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |