Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CCKBR | P32239 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7523636 | 0.85 | CYP2D6 (0.53) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL2724342 | 0.83 | KDM4E (0.69) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7521494 | 0.82 | KDM4E (0.53) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7525817 | 0.81 | KDM4E (0.62) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL23116634 | 0.81 | MEN1 (0.72) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7519979 | 0.79 | CYP2D6 (0.67) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL7522074 | 0.77 | SSTR3 (0.58) | MEN1KMT2AKDM4EALDH1A1TSHR | |
| SCHEMBL28344589 | 0.74 | CYP2D6 (0.64) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL28334395 | 0.74 | CYP2D6 (0.64) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL28344541 | 0.74 | CYP2D6 (0.64) | MEN1KMT2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891187-B1 | USE OF DERIVATIVES OF TETRAHYDRO-BETA-CARBOLINES AS ANTIMETASTATIC AGENTS | HOFFMANN LA ROCHE (CH) | 2002-01-30 | — | — | EP | claimed |