SCHEMBL7522074

SCHEMBL7522074

COc1ccc(C2NC(OC(=O)O)Cc3c2[nH]c2ccccc32)cc1

nearest known ligand 0.58

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SSTR3 P32745 1/20 0.58
HDAC1 Q13547 2/20 0.55
HDAC6 Q9UBN7 2/20 0.55
CCKBR P32239 2/20 0.55
MEN1 O00255 3/20 0.55
KMT2A Q03164 3/20 0.55
ALDH1A1 P00352 2/20 0.55
ALOX12 P18054 1/20 0.55
CYP2D6 P10635 2/20 0.55
TSHR P16473 1/20 0.55
MAPK1 P28482 1/20 0.55
KDM4E B2RXH2 1/20 0.53
CYP2C19 P33261 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
ABCB1 P08183 2/20 0.51
ABCG2 Q9UNQ0 2/20 0.51
PDE5A O76074 3/20 0.49
DHODH Q02127 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7519979 0.90 CYP2D6 (0.67) HDAC1HDAC6CCKBRMEN1KMT2A
SCHEMBL13568945 0.84 CYP2D6 (0.78) SSTR3HDAC1HDAC6CCKBRMEN1
SCHEMBL18254530 0.84 CYP2D6 (0.78) SSTR3HDAC1HDAC6CCKBRMEN1
SCHEMBL1921430 0.84 CYP2D6 (0.78) SSTR3HDAC1HDAC6CCKBRMEN1
SCHEMBL12967991 0.81 CCKBR (0.82) SSTR3HDAC1HDAC6CCKBRMEN1
SCHEMBL16489369 0.81 CCKBR (0.82) SSTR3HDAC1HDAC6CCKBRMEN1
SCHEMBL12967653 0.81 CCKBR (0.82) SSTR3HDAC1HDAC6CCKBRMEN1
SCHEMBL1922130 0.81 CCKBR (0.82) SSTR3HDAC1HDAC6CCKBRMEN1
SCHEMBL1921747 0.81 CCKBR (0.82) SSTR3HDAC1HDAC6CCKBRMEN1
SCHEMBL7525817 0.80 KDM4E (0.62) CCKBRMEN1KMT2AALDH1A1ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0891187-B1 USE OF DERIVATIVES OF TETRAHYDRO-BETA-CARBOLINES AS ANTIMETASTATIC AGENTS HOFFMANN LA ROCHE (CH) 2002-01-30 EP claimed