Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.58 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 4/20 | 0.56 |
| ▸ | CA2 | P00918 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TOP1 | P11387 | 3/20 | 0.55 |
| ▸ | PTPRC | P08575 | 2/20 | 0.54 |
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA7 | P43166 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11672759 | 0.86 | EGLN1 (0.61) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL29195031 | 0.84 | KDM4E (0.53) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL6337602 | 0.84 | CA1 (0.55) | HDAC6KDM4EMAPTHIF1ASLC22A6 | |
| SCHEMBL29195064 | 0.84 | CA2 (0.62) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL3187483 | 0.82 | SIRT5 (0.58) | HDAC6KDM4EMAPTCA1CA2 | |
| SCHEMBL11107537 | 0.82 | KDM4E (0.80) | HDAC6KDM4EMAPTHIF1ASLC22A6 | |
| SCHEMBL16144996 | 0.81 | KDM4E (0.59) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL23067305 | 0.81 | HDAC6 (0.53) | HDAC6KDM4EMAPTHIF1ACA1 | |
| SCHEMBL31465194 | 0.80 | HTT (0.61) | HDAC6KDM4EMAPTHIF1ASLC22A6 | |
| SCHEMBL6138174 | 0.80 | HTT (0.61) | HDAC6KDM4EMAPTHIF1ASLC22A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362165-B1 | Hydroxyphenyl derivatives with HIV integrase inhibitory properties | PHARMACOR INC. (CA) | 2002-03-26 | — | — | US | disclosed |
| EP-1165492-A1 | HYDROXYPHENYL DERIVATIVES WITH HIV INTEGRASE INHIBITORY PROPERTIES | Pharmacor Inc. (CA) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059867-A1 | HYDROXYPHENYL DERIVATIVES WITH HIV INTEGRASE INHIBITORY PROPERTIES | PHARMACOR INC. (CA) | 2000-10-12 | — | — | WO | disclosed |