Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7516041 | 0.90 | ALDH1A1 (0.36) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL7519327 | 0.88 | GAA (0.35) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL8578900 | 0.86 | HPN (0.42) | ALDH1A1ALOX15CYP2C9TYRTSHR | |
| SCHEMBL7526663 | 0.86 | ALDH1A1 (0.36) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL7525362 | 0.84 | ALDH1A1 (0.40) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL7521627 | 0.83 | ALDH1A1 (0.41) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL7526421 | 0.83 | ALDH1A1 (0.39) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL7521927 | 0.82 | ALOX15 (0.40) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL7523766 | 0.80 | ALDH1A1 (0.44) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| Butyric Acid SCHEMBL27517478 | 0.77 | HSP90AA1 (0.34) | ALDH1A1ALOX15CYP2C9NR1I2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| CN-1216993-A | alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL INC (US) | 1999-05-19 | — | — | CN | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |