Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7516430 | 0.92 | ALDH1A1 (0.42) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL7523766 | 0.85 | ALDH1A1 (0.44) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL8577784 | 0.84 | HPN (0.46) | ALDH1A1ALOX15LMNATYRGAA | |
| SCHEMBL7519327 | 0.82 | GAA (0.35) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL9190675 | 0.81 | HPN (0.46) | ALDH1A1ALOX15LMNATYRGAA | |
| SCHEMBL7527873 | 0.79 | ALOX15 (0.43) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL7525061 | 0.79 | ALDH1A1 (0.41) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL9143477 | 0.78 | AR (0.45) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL7523538 | 0.78 | ALDH1A1 (0.46) | ALDH1A1ALOX15CYP2C9NR1I2LMNA | |
| SCHEMBL7516041 | 0.76 | ALDH1A1 (0.36) | ALDH1A1ALOX15CYP2C9NR1I2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| CN-1216993-A | alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL INC (US) | 1999-05-19 | — | — | CN | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |