SCHEMBL7521972

SCHEMBL7521972

C=CCN(CC=C)Cc1c(C)ccc2[nH]c(=O)c(=O)[nH]c12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.53
MAPT P10636 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
ALDH1A1 P00352 3/20 0.42
MEN1 O00255 1/20 0.42
GAA P10253 1/20 0.42
HPGD P15428 1/20 0.42
KMT2A Q03164 1/20 0.42
GRIN2D O15399 2/20 0.38
GRIN3B O60391 2/20 0.38
GRIN1 Q05586 2/20 0.38
GRIN2A Q12879 2/20 0.38
GRIN2B Q13224 2/20 0.38
GRIN2C Q14957 2/20 0.38
GRIN3A Q8TCU5 2/20 0.38
HSD17B10 Q99714 1/20 0.38
GRIA1 P42261 3/20 0.38
GRIA2 P42262 3/20 0.38
GRIA3 P42263 3/20 0.38
GRIA4 P48058 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7949962 0.74 SMN1; SMN2 (0.52) KDM4EALDH1A1MEN1GAAHPGD
SCHEMBL8169596 0.71 HSD17B10 (0.42) KDM4EMAPTALDH1A1GAAHPGD
SCHEMBL7593716 0.70 GRIA1 (0.61) KDM4EMAPTL3MBTL1ALDH1A1MEN1
SCHEMBL8634867 0.70 GRIN2D (0.44) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL7948487 0.70 HSD17B10 (0.44) KDM4EMAPTALDH1A1GAAHPGD
SCHEMBL7529844 0.67 KDM4E (0.44) KDM4EMAPTL3MBTL1ALDH1A1MEN1
SCHEMBL7957683 0.66 GRIN2D (0.50) KDM4EGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL8037105 0.66 CFB (0.48) KDM4EMAPTL3MBTL1ALDH1A1MEN1
SCHEMBL8040463 0.65 CFB (0.50) KDM4EMAPTL3MBTL1ALDH1A1MEN1
SCHEMBL8037118 0.65 CFB (0.50) KDM4EMAPTL3MBTL1ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0837854-B1 ALKYL AMINE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS WARNER LAMBERT CO (US) 2002-12-11 EP disclosed
EP-0830348-B1 CYCLIC AMINE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS WARNER LAMBERT CO (US) 2002-09-04 EP disclosed
US-6110911-A ADMINISTERING NEUROPROTECTANT/ANTICONVULSANT TO PATIENT WARNER-LAMBERT COMPANY (US) 2000-08-29 US disclosed
US-5874426-A USEFUL IN THE TREATMENT OF STROKE, CEREBRAL ISCHEMIA, OR CEREBRAL INFARCTION RESULTING FROM THROMBOEMBOLIC OR HEMORRHAGIC STROKE, CEREBRAL VASOSPASMS, HYPOGLYCEMIA, CARDIAC ARREST, STATUS EPILEPTICUS, ANOXIA, SEIZURE DISORDER WARNER-LAMBERT COMPANY (US) 1999-02-23 US disclosed
EP-0837854-A1 ALKYL AMINE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1998-04-29 EP disclosed
EP-0830348-A1 CYCLIC AMINE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1998-03-25 EP disclosed
US-5654303-A FOR TREATING NERVOUS SYSTEM OR CARDIOVASCULAR SYSTEM DISORDERS WARNER-LAMBERT COMPANY (US) 1997-08-05 US disclosed
WO-1996040650-A1 CYCLIC AMINE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1996-12-19 WO disclosed
WO-1996040651-A1 ALKYL AMINE DERIVATIVES OF SUBSTITUTED QUINOXALINE 2,3-DIONES AS GLUTAMATE RECEPTOR ANTAGONISTS WARNER-LAMBERT COMPANY (US) 1996-12-19 WO disclosed