Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.43 |
| ▸ | SLC29A1 | Q99808 | 3/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14269185 | 0.91 | HRH4 (0.36) | HRH4SLC29A1NUDT1SMN1; SMN2LMNA | |
| SCHEMBL6399183 | 0.87 | NUDT1 (0.41) | HRH4NUDT1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL7523111 | 0.83 | NUDT1 (0.38) | HRH4NUDT1SMN1; SMN2CYP1A2KMT2A | |
| SCHEMBL6761125 | 0.80 | NUDT1 (0.52) | HRH4NUDT1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL7512888 | 0.79 | HTT (0.55) | HRH4SMN1; SMN2LMNACYP1A2TSHR | |
| SCHEMBL6397494 | 0.78 | NUDT1 (0.51) | HRH4NUDT1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL14269186 | 0.78 | BCHE (0.35) | NUDT1ALDH1A1MAPTPOLB | |
| Minoxidil SCHEMBL1318033 | 0.76 | SMN1; SMN2 (0.44) | HRH4NUDT1SMN1; SMN2LMNACYP1A2 | |
| Minoxidil SCHEMBL29698 | 0.74 | SMN1; SMN2 (0.47) | HRH4NUDT1SMN1; SMN2LMNACYP1A2 | |
| Minoxidil SCHEMBL638820 | 0.74 | SMN1; SMN2 (0.47) | HRH4NUDT1SMN1; SMN2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0829260-B1 | Use of at least one pyrimidine derivative substituted in position 6 as stimulant of tyrosinase | OREAL (FR) | 2002-05-15 | — | — | EP | claimed |
| US-20020103216-A1 | Administering topically a tyrosinase activity-stimulating amount of a 6-substituted pyrimidine 3-oxide | PRUCHE FRANCIS (FR) | 2002-08-01 | — | — | US | disclosed |
| US-6380263-B1 | ADMINISTERING TO HUMAN EFFECTIVE TYROSINASE ACTIVITY-STIMULATING AMOUNT OF AT LEAST ONE 6-SUBSTITUTED PYRIMIDINE 3-OXIDE COMPOUND FOR PROMOTING PIGMENTATION OF THE SKIN AND/OR HAIR | SOCIETE L'OREAL (FR) | 2002-04-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103216-A1 | Administering topically a tyrosinase activity-stimulating amount of a 6-substituted pyrimidine 3-oxide | TYR, TH, MC1R | HRH4 412/4885SLC29A1 2119/4885NUDT1 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.