Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Minoxidil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 6/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP4 | P49662 | 1/20 | 0.39 |
| ▸ | CASP5 | P51878 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Minoxidil SCHEMBL8860979 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL638820 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL29365549 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL5080820 | 0.98 | SMN1; SMN2 (0.46) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL7634414 | 0.98 | SMN1; SMN2 (0.46) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL6242048 | 0.98 | SMN1; SMN2 (0.46) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL3137104 | 0.98 | SMN1; SMN2 (0.46) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL8080441 | 0.98 | SMN1; SMN2 (0.46) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| SCHEMBL5309809 | 0.98 | HRH4 (0.46) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 | |
| Minoxidil SCHEMBL22189162 | 0.92 | SMN1; SMN2 (0.42) | SMN1; SMN2CRHBPCRHR2HRH4NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 40051 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144791-A1 | COMPOSITIONS AND METHODS OF USE FOR MODIFIED RELEASE MINOXIDIL | VERADERMICS, INCORPORATED (US) | 2026-05-28 | — | — | US | claimed |
| US-20260144790-A1 | COMPOSITIONS AND METHODS OF USE FOR MODIFIED RELEASE MINOXIDIL | VERADERMICS, INCORPORATED (US) | 2026-05-28 | — | — | US | claimed |
| CN-122080930-A | Minoxidil-based tunable room-temperature phosphorescent carbon dot composite material, preparation method and application thereof in dynamic information encryption | — | 2026-05-26 | — | — | CN | claimed |
| CN-120771261-B | Composition containing cerium oxide nano enzyme and application thereof | SHANDONG HUBBLE KISEN BIOLOGICAL TECHNOLOGY Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122070900-A | In situ gel composition containing penomelin | 南京迈诺威医药科技有限公司 | 2026-05-22 | — | — | CN | claimed |
| WO-2026107401-A2 | COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF POLYLACTIC ACID FOR HAIR GROWTH | DURAIRAJ KALPNA KAY (US) | 2026-05-21 | — | — | WO | claimed |
| WO-2026106917-A1 | EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL | BioPhysics Pharma, Inc. (US) | 2026-05-21 | — | — | WO | claimed |
| CN-122070133-A | Pharmaceutical compositions containing androgen receptor inhibitors/antagonists, methods and uses | 苏州开拓药业股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-117137867-B | Foam type cation nanoemulsion hair growth promoting liquid and preparation method thereof | 苏州大学 | 2026-05-19 | — | — | CN | claimed |
| CN-122060683-A | Human mesenchymal stem cell edited by RSPO3 mRNA and application thereof | 四川康德赛医疗科技有限公司 | 2026-05-19 | — | — | CN | claimed |
| EP-0081094-A1 | Substituted omega-amino-carboxymethyldipeptide antihypertensive agents | MERCK & CO. INC. (US) | 1983-06-15 | — | — | EP | claimed |
| EP-0079522-A1 | N-Carboxymethyl(amidino)lysyl-proline antihypertensive agents | MERCK & CO. INC. (US) | 1983-05-25 | — | — | EP | claimed |
| EP-0061186-A1 | Dipeptides containing thialysine and homologs as antihypertensives | MERCK & CO. INC. (US) | 1982-09-29 | — | — | EP | claimed |
| EP-0061187-A1 | Bicyclic lactams as antihypertensives | MERCK & CO. INC. (US) | 1982-09-29 | — | — | EP | claimed |
| EP-0049842-A2 | Substituted enantholactam derivatives, a process for the preparation and a pharmaceutical composition useful in the treatment of hypertension comprising the same, and intermediates | MERCK & CO. INC. (US) | 1982-04-21 | — | — | EP | claimed |
| EP-0049505-A2 | Substituted caprolactam derivatives, a process for preparing and a pharmaceutical composition containing the same, and intermediates | MERCK & CO. INC. (US) | 1982-04-14 | — | — | EP | claimed |
| EP-0046289-A2 | Substituted enantholactam derivatives as antihypertensives, a process for preparing and a pharmaceutical composition containing them, and intermediates | MERCK & CO. INC. (US) | 1982-02-24 | — | — | EP | claimed |
| EP-0046291-A2 | Substituted caprolactam derivatives as antihypertensives, process for preparing them, pharmaceutical composition containing them, and intermediates | MERCK & CO. INC. (US) | 1982-02-24 | — | — | EP | claimed |
| US-4308271-A | PYRIMIDINE OXIDE DERIVATIVES TO INCREASE PRODUCTION | THE UPJOHN COMPANY (US) | 1981-12-29 | — | — | US | claimed |
| US-4282228-A | Animal feed and process | THE UPJOHN COMPANY (US) | 1981-08-04 | — | — | US | claimed |