Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 2/20 | 0.32 |
| ▸ | CDK8 | P49336 | 2/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.32 |
| ▸ | BRS3 | P32247 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27394755 | 0.84 | MMP2 (0.43) | MMP2MMP9MMP13BAZ2BBRS3 | |
| SCHEMBL27807589 | 0.75 | MMP2 (0.36) | MMP2MMP9MMP13MAP2K1PDPK1 | |
| SCHEMBL23337994 | 0.73 | MMP2 (0.50) | MMP2MMP9MMP13DAOBRS3 | |
| SCHEMBL8308592 | 0.70 | MAP2K1 (0.38) | MAP2K1PDPK1CCNCCDK8BAZ2B | |
| SCHEMBL19339784 | 0.68 | — | — | |
| SCHEMBL759817 | 0.68 | — | — | |
| SCHEMBL14249526 | 0.67 | CCNC (0.47) | MMP2CCNCCDK8 | |
| Trifluoroacetic Acid SCHEMBL28784262 | 0.67 | MMP2 (0.34) | MMP2MMP9MMP13HRH1 | |
| SCHEMBL10869963 | 0.67 | PIN1 (0.39) | MAP2K1PDPK1CCNCCDK8DAO | |
| SCHEMBL14744177 | 0.67 | MMP2 (0.67) | MMP2MMP9MMP13HTR1BHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202984-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | AstraZeneca UK Limited (GB) | 2002-05-08 | — | — | EP | claimed |
| WO-2001005782-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LIMITED (GB) | 2001-01-25 | — | — | WO | claimed |
| EP-1202984-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | AstraZeneca UK Limited (GB) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005782-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LIMITED (GB) | 2001-01-25 | — | — | WO | disclosed |