Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 1-Naphthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.81 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.56 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.56 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LDHA | P00338 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CDC25B | P30305 | 1/20 | 0.48 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Naphthol SCHEMBL29053779 | 0.93 | CYP1A2 (0.77) | CYP1A2NR4A1NR4A2NR4A3GRIN2D | |
| 1-Naphthol SCHEMBL28299887 | 0.93 | CYP1A2 (0.94) | CYP1A2NR4A1NR4A2NR4A3HSD17B10 | |
| 1-Naphthol SCHEMBL27708110 | 0.93 | CYP1A2 (0.94) | CYP1A2NR4A1NR4A2NR4A3HSD17B10 | |
| 1-Naphthol SCHEMBL1656111 | 0.91 | CYP1A2 (0.74) | CYP1A2NR4A1NR4A2NR4A3GRIN2D | |
| 1-Naphthol SCHEMBL29767730 | 0.90 | CYP1A2 (1.00) | CYP1A2HSD17B10KDM4EALDH1A1HPGD | |
| 1-Naphthol SCHEMBL10486461 | 0.90 | CYP1A2 (1.00) | CYP1A2HSD17B10KDM4EALDH1A1HPGD | |
| 1-Naphthol SCHEMBL273260 | 0.90 | CYP1A2 (1.00) | CYP1A2HSD17B10KDM4EALDH1A1HPGD | |
| 1-Naphthol SCHEMBL3416 | 0.90 | CYP1A2 (1.00) | CYP1A2HSD17B10KDM4EALDH1A1HPGD | |
| 1-Naphthol SCHEMBL356271 | 0.88 | CYP1A2 (0.77) | CYP1A2NR4A1NR4A2NR4A3GRIN2D | |
| 1-Naphthol SCHEMBL5685505 | 0.88 | CYP1A2 (0.63) | CYP1A2NR4A1NR4A2NR4A3GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0803492-B1 | METHOD FOR SEPARATING AND PURIFYING HYDROXYNAPHTHALENECARBOXYLIC ACIDS | UENO SEIYAKU OYO KENKYUJO KK (JP) | 2002-02-06 | — | — | EP | claimed |
| JP-2086611-A | — | — | None | — | — | JP | disclosed |
| EP-0556556-B1 | Basic azo dyestuffs from coupling components of the hydroxynaphthalene carbonic acid series | BASF AG (DE) | 1997-04-09 | — | — | EP | disclosed |
| EP-0556556-A1 | Basic azo dyestuffs from coupling components of the hydroxynaphthalene carbonic acid series | BASF Aktiengesellschaft (DE) | 1993-08-25 | — | — | EP | disclosed |
| JP-H0286611-A | SURFACE ACTIVE COMPOUND WITH HYDROXY NAPHTHOIC ACID ESTER AS SUPPORT BODY AND ITS PREPARATION AND USE THEREOF | HOECHST AG | 1990-03-27 | — | — | JP | disclosed |