SCHEMBL7523041

SCHEMBL7523041

Cn1nccc1-c1ccc2c(C3=C(c4cn(C)c5cc(Br)ccc45)C(=O)NC3=O)cn(C)c2c1

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 9/20 0.54
CDK4 P11802 3/20 0.51
CCND1 P24385 3/20 0.51
CDK2 P24941 3/20 0.51
CCNE2 O96020 2/20 0.51
CCNE1 P24864 2/20 0.51
CAMK2D Q13557 1/20 0.48
QPCT Q16769 3/20 0.47
CCNT1 O60563 1/20 0.46
CDK1 P06493 1/20 0.46
CCNB1 P14635 1/20 0.46
CCND3 P30281 1/20 0.46
CDK9 P50750 1/20 0.46
CDK3 Q00526 1/20 0.46
CDK6 Q00534 1/20 0.46
CDK5 Q00535 1/20 0.46
CDK5R1 Q15078 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7523424 0.88 CDK2 (0.63) GSK3BCDK4CCND1CDK2CCNE2
SCHEMBL7524287 0.85 CDK2 (0.44) GSK3BCDK4CCND1CDK2CCNE2
SCHEMBL7529336 0.78 CCNE2 (0.77) GSK3BCDK4CCND1CDK2CCNE2
SCHEMBL7500917 0.77 GSK3B (0.59) GSK3BCDK4CCND1CDK2CCNE2
SCHEMBL7990763 0.76 GSK3B (0.58) GSK3BCDK4CCND1CDK2CCNE2
SCHEMBL7499634 0.76 GSK3B (0.55) GSK3BCDK4CCND1CDK2CCNE2
SCHEMBL7976579 0.74 GSK3B (0.56) GSK3BCDK4CCND1CDK2CCNE2
SCHEMBL7524890 0.74 GSK3B (0.56) GSK3BCDK4CCND1CDK2CCNE2
SCHEMBL7529269 0.73 GSK3B (0.54) GSK3BCDK4CCND1CDK2CCNE2
SCHEMBL7536246 0.71 CCNE2 (0.63) GSK3BCDK4CCND1CDK2CCNE2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6281356-B1 ANTICANRCER AGENTS HOFFMANN-LA ROCHE INC. 2001-08-28 US claimed
EP-1242409-A2 SUBSTITUTED BISINDOLYLMALEIMIDES F. HOFFMANN-LA ROCHE AG (CH) 2002-09-25 EP disclosed
US-6281356-B1 ANTICANRCER AGENTS HOFFMANN-LA ROCHE INC. 2001-08-28 US disclosed
WO-2001046178-A2 SUBSTITUIERTE BISINDOLYMALEIMIDE F. HOFFMANN-LA ROCHE AG (CH) 2001-06-28 WO disclosed