Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.58 |
| ▸ | CDK2 | P24941 | 3/20 | 0.53 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.53 |
| ▸ | CDK4 | P11802 | 2/20 | 0.53 |
| ▸ | CCND1 | P24385 | 2/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.53 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.50 |
| ▸ | QPCT | Q16769 | 5/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7597933 | 0.89 | CDK2 (0.63) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7988008 | 0.84 | CDK2 (0.45) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7524890 | 0.81 | GSK3B (0.56) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7529336 | 0.80 | CCNE2 (0.77) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7529269 | 0.78 | GSK3B (0.54) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7500917 | 0.76 | GSK3B (0.59) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7976579 | 0.76 | GSK3B (0.56) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7523041 | 0.76 | GSK3B (0.54) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7499634 | 0.73 | GSK3B (0.55) | GSK3BCDK2CCNE2CDK4CCND1 | |
| SCHEMBL7531023 | 0.72 | CDK2 (0.62) | GSK3BCDK2CCNE2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | claimed |
| US-6281356-B1 | ANTICANRCER AGENTS | HOFFMANN-LA ROCHE INC. | 2001-08-28 | — | — | US | disclosed |