Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 8/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | Q9HBH1 | 1/20 | 0.35 | |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2707653 | 0.84 | HPGDS (0.42) | MAPK13MAPK12MAPK11MAPK14PRCP | |
| SCHEMBL203907 | 0.84 | HPGDS (0.42) | MAPK13MAPK12MAPK11MAPK14PRCP | |
| SCHEMBL206727 | 0.83 | ADAM10 (0.42) | MAPK13MAPK12MAPK11MAPK14PRCP | |
| SCHEMBL2707006 | 0.83 | ADAM10 (0.42) | MAPK13MAPK12MAPK11MAPK14PRCP | |
| SCHEMBL3477648 | 0.83 | CYP3A4 (0.52) | PRCPNR1I2ABCB11CYP3A4CYP2C9 | |
| SCHEMBL204930 | 0.82 | CYP3A4 (0.40) | PRCPNR1I2ABCB11CYP3A4CYP2C9 | |
| SCHEMBL19339456 | 0.81 | CYP3A4 (0.43) | MAPK13MAPK12MAPK11MAPK14PRCP | |
| SCHEMBL15586557 | 0.79 | CYP3A4 (0.64) | PRCPNR1I2ABCB11CYP3A4CYP2C9 | |
| SCHEMBL204761 | 0.79 | CYP3A4 (0.64) | PRCPNR1I2ABCB11CYP3A4CYP2C9 | |
| SCHEMBL2707003 | 0.79 | CYP3A4 (0.64) | PRCPNR1I2ABCB11CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430014-A1 | ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132601-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2010-11-18 | — | — | WO | disclosed |