Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28986677 | 0.79 | ALDH1A1 (0.54) | ALDH1A1MAPTL3MBTL1HRH3KCNH2 | |
| SCHEMBL171395 | 0.72 | ALDH1A1 (0.56) | ALDH1A1MAPTL3MBTL1TAAR1MEN1 | |
| SCHEMBL232188 | 0.72 | MAPT (0.78) | ALDH1A1MAPTL3MBTL1DRD4HRH3 | |
| SCHEMBL6842001 | 0.72 | MAPT (0.45) | ALDH1A1MAPTL3MBTL1MEN1MITF | |
| SCHEMBL6573773 | 0.71 | ALDH1A1 (0.44) | ALDH1A1MAPTL3MBTL1DRD4HRH3 | |
| SCHEMBL1562142 | 0.70 | MAPT (0.74) | ALDH1A1MAPTL3MBTL1DRD4HRH3 | |
| SCHEMBL6416019 | 0.70 | MAPT (0.74) | ALDH1A1MAPTL3MBTL1DRD4HRH3 | |
| SCHEMBL473377 | 0.69 | DRD4 (0.52) | ALDH1A1MAPTL3MBTL1DRD4KCNH2 | |
| SCHEMBL12337252 | 0.69 | MAPT (0.52) | ALDH1A1MAPTL3MBTL1DRD4HRH3 | |
| SCHEMBL11692138 | 0.69 | DRD4 (0.52) | ALDH1A1MAPTL3MBTL1DRD4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1195371-A1 | PROCESS FOR THE PREPARATION OF TRICYCLIC AMINO ALCOHOL DERIVATIVES | Asahi Kasei Kabushiki Kaisha (JP) | 2002-04-10 | — | — | EP | disclosed |
| EP-1174426-A1 | METHOD FOR THE PREPARATION OF TRICYCLIC AMINO ALCOHOL DERIVATIVES THROUGH AZIDES | Asahi Kasei Kabushiki Kaisha (JP) | 2002-01-23 | — | — | EP | disclosed |