Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.32 |
| ▸ | TMPRSS15 | P98073 | 2/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7202680 | 0.84 | CHRNA7 (0.46) | — | |
| SCHEMBL6501667 | 0.81 | CHRNA7 (0.41) | ABL1 | |
| SCHEMBL6496980 | 0.73 | HCAR2 (0.44) | CYP3A4HSD17B10ALDH1A1TMPRSS15USP30 | |
| SCHEMBL28474114 | 0.72 | ALDH1A1 (0.41) | ALDH1A1TMPRSS15USP30ABL1TSHR | |
| SCHEMBL6496922 | 0.71 | CDC7 (0.46) | HSD17B10ALDH1A1TMPRSS15USP30HPGD | |
| SCHEMBL7652150 | 0.68 | CHRNA7 (0.51) | — | |
| SCHEMBL12715430 | 0.67 | PAX8 (0.41) | ALDH1A1LMNAUSP30ABL1TSHR | |
| SCHEMBL12744103 | 0.66 | USP30 (0.39) | ALDH1A1USP30ABL1TSHR | |
| SCHEMBL11723390 | 0.65 | HSD17B10 (0.45) | CYP3A4HSD17B10ALDH1A1HTTLMNA | |
| SCHEMBL12824358 | 0.65 | ALDH1A1 (0.44) | CYP3A4ALDH1A1USP30KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002015662-A2 | QUINUCLIDINE-SUBSTITUTED HETEROARYL MOIETIES FOR TREATMENT OF DISEASE (NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-02-28 | — | — | WO | disclosed |
| WO-2002017358-A2 | QUINUCLIDINE-SUBSTITUTED HETEROARYL MOIETIES FOR TREATMENT OF DISEASE (NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS) | PHARMACIA & UPJOHN COMPANY (US) | 2002-02-28 | — | — | WO | disclosed |