Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.52 |
| ▸ | MAOB | P27338 | 4/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.49 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.49 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375569 | 0.92 | GRIN2D (0.57) | LTA4HMAOBGRIN2DGRIN3BMAPT | |
| SCHEMBL7405065 | 0.85 | TMEM97 (0.62) | LTA4HMAOBGRIN2DGRIN3BMAPT | |
| Hydrochloric Acid SCHEMBL7406531 | 0.84 | TMEM97 (0.61) | LTA4HMAOBGRIN2DGRIN3BMAPT | |
| Hydrochloric Acid SCHEMBL7374837 | 0.81 | TMEM97 (0.61) | LTA4HMAOBTMEM97SIGMAR1KDM4E | |
| SCHEMBL7380357 | 0.81 | GRIN2B (0.55) | LTA4HMAOBGRIN2BTMEM97SIGMAR1 | |
| SCHEMBL7505451 | 0.79 | TMEM97 (0.70) | LTA4HMAOBTMEM97SIGMAR1KDM4E | |
| Fumaric Acid SCHEMBL7298436 | 0.77 | GRIN2B (0.84) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| Fumaric Acid SCHEMBL7298465 | 0.77 | GRIN2B (0.84) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL7400054 | 0.76 | TMEM97 (0.62) | LTA4HMAOBTMEM97SIGMAR1 | |
| SCHEMBL7405581 | 0.76 | TMEM97 (0.62) | LTA4HMAOBTMEM97SIGMAR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997023202-A1 | SUBTYPE-SELECTIVE NMDA RECEPTOR LIGANDS AND THE USE THEREOF | STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON (US) | 1997-07-03 | — | — | WO | disclosed |