Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 10/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7515459 | 0.73 | IDO1 (0.43) | IDO1NCOA1NCOA3EGFRMAP2K1 | |
| SCHEMBL29961547 | 0.72 | RAPGEF4 (0.61) | IDO1EGFRRAPGEF4MEN1LMNA | |
| SCHEMBL29961149 | 0.72 | RAPGEF4 (0.61) | IDO1EGFRRAPGEF4MEN1LMNA | |
| SCHEMBL1687027 | 0.72 | RAPGEF4 (0.61) | IDO1EGFRRAPGEF4MEN1LMNA | |
| SCHEMBL18786726 | 0.71 | MKNK1 (0.55) | — | |
| SCHEMBL18786724 | 0.69 | MKNK1 (0.34) | — | |
| SCHEMBL7519427 | 0.68 | GRM4 (0.44) | MAP2K1RAPGEF4MEN1KMT2A | |
| SCHEMBL7294506 | 0.68 | PIM1 (0.41) | RAPGEF4MEN1NPC1LMNARAB9A | |
| SCHEMBL72905 | 0.67 | MEN1 (0.68) | EGFRRAPGEF4MEN1LMNAALOX15 | |
| SCHEMBL13602809 | 0.66 | KMT2A (0.50) | MEN1NPC1LMNAALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173420-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | Novuspharma S.p.A. (IT) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000053581-A2 | HETEROCYCLIC COMPOUNDS HAVING ANTITUMOR ACTIVITY | NOVUSPHARMA S.P.A. (IT) | 2000-09-14 | — | — | WO | disclosed |