Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8683168 | 0.73 | CA12 (0.55) | GAAALDH1A1HSD17B10TSHRNFKB1 | |
| SCHEMBL6035395 | 0.68 | ALDH1A1 (0.52) | GAAALDH1A1HSD17B10TSHRNFKB1 | |
| SCHEMBL14126063 | 0.67 | CXCL8 (0.49) | GAAALDH1A1HSD17B10TSHRNFKB1 | |
| SCHEMBL31446274 | 0.67 | AKR1B1 (0.67) | ALDH1A1HSD17B10POLBSMN1; SMN2LMNA | |
| SCHEMBL29431257 | 0.67 | CXCL8 (0.49) | GAAALDH1A1HSD17B10TSHRNFKB1 | |
| SCHEMBL17681784 | 0.67 | CA12 (0.47) | GAAALDH1A1HSD17B10TSHRNFKB1 | |
| SCHEMBL11790880 | 0.67 | HTT (0.53) | ALDH1A1HSD17B10TSHRTDP1POLB | |
| SCHEMBL17006218 | 0.67 | ANO1 (0.47) | GAAALDH1A1HSD17B10TSHRNFKB1 | |
| SCHEMBL4435429 | 0.67 | AKR1B1 (0.67) | ALDH1A1HSD17B10POLBSMN1; SMN2LMNA | |
| SCHEMBL5175430 | 0.66 | CA1 (0.45) | GAAALDH1A1TSHRTDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | disclosed |