Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | GAA | P10253 | 1/20 | 0.75 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 4/20 | 0.60 |
| ▸ | SNCA | P37840 | 2/20 | 0.59 |
| ▸ | FDPS | P14324 | 3/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA3 | P07451 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7525306 | 1.00 | KDM4E (0.86) | KDM4EKMT2AGAAPOLBAKR1C3 | |
| SCHEMBL7246269 | 0.96 | KDM4E (0.82) | KDM4EKMT2AGAAPOLBAKR1C3 | |
| SCHEMBL4623935 | 0.96 | KDM4E (0.82) | KDM4EKMT2AGAAPOLBAKR1C3 | |
| SCHEMBL3694597 | 0.93 | KDM4E (1.00) | KDM4EKMT2AGAAPOLBAKR1C3 | |
| SCHEMBL11231174 | 0.93 | KDM4E (0.90) | KDM4EKMT2AGAAPOLBAKR1C3 | |
| SCHEMBL3694599 | 0.93 | KDM4E (1.00) | KDM4EKMT2AGAAPOLBAKR1C3 | |
| SCHEMBL11231173 | 0.93 | KDM4E (0.90) | KDM4EKMT2AGAAPOLBAKR1C3 | |
| SCHEMBL7524744 | 0.93 | KDM4E (0.75) | KDM4EKMT2AGAAPOLBAKR1C3 | |
| SCHEMBL7524738 | 0.93 | KDM4E (0.75) | KDM4EKMT2AGAAPOLBAKR1C3 | |
| SCHEMBL6513271 | 0.90 | KDM4E (0.71) | KDM4EKMT2AGAAPOLBAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020128231-A1 | Aryl-indane compounds | EASTMAN CHEMICAL COMPANY | 2002-09-12 | — | — | US | disclosed |
| WO-2002030915-A2 | ARYL-INDANE COMPOUNDS FOR USE AS INHIBITORS OF P-GLYCOPROTEIN MEDIATED TRANSPORT | AVLAN LIMITED (GB) | 2002-04-18 | — | — | WO | disclosed |
| US-5559109-A | Method of treating a PAF-mediated pathology or for treating or preventing psoriasis, nephritis, asthma or shock by administering a PAF antagonist | SANKKO COMPANY, LIMITED (JP) | 1996-09-24 | — | — | US | disclosed |
| US-5556852-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0395446-B1 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | SANKYO CO (JP) | 1995-03-01 | — | — | EP | disclosed |
| US-5369106-A | N-acryloylpiperazine derivatives, their preparation and their use of PAF antagonists | SANKYO COMPANY, LIMITED (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5192766-A | Platelet activating factor antagonist | SANKYO COMPANY, LIMITED (JP) | 1993-03-09 | — | — | US | disclosed |
| EP-0395446-A2 | N-acryloylpiperazine derivatives, their preparation and their use as paf antagonists | Sankyo Company Limited (JP) | 1990-10-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128231-A1 | Aryl-indane compounds | ABCB1, ABCC1, ABCG2 | KDM4E 3633/4885KMT2A 4047/4885GAA 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.