Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 14/20 | 0.54 |
| ▸ | CDK2 | P24941 | 7/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.54 |
| ▸ | CCND3 | P30281 | 4/20 | 0.54 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.54 |
| ▸ | CCND1 | P24385 | 11/20 | 0.52 |
| ▸ | CDK1 | P06493 | 5/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.50 |
| ▸ | CCND2 | P30279 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.48 |
| ▸ | CDK7 | P50613 | 3/20 | 0.48 |
| ▸ | CDK9 | P50750 | 3/20 | 0.48 |
| ▸ | CCNH | P51946 | 3/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086788 | 0.81 | CDK4 (0.57) | CDK4CDK2CCNA2CCND3CDK6 | |
| SCHEMBL6087139 | 0.80 | CDK4 (0.58) | CDK4CDK2CCNA2CCND3CDK6 | |
| SCHEMBL6086902 | 0.73 | CDK4 (0.61) | CDK4CDK2CCNA2CCND3CDK6 | |
| SCHEMBL1115237 | 0.72 | FLT3 (0.53) | CDK4CDK2CCNA2CCND3CDK6 | |
| SCHEMBL6086831 | 0.72 | CDK4 (0.61) | CDK4CDK2CCNA2CCND3CDK6 | |
| SCHEMBL6087196 | 0.71 | CDK4 (0.49) | CDK4CDK2CCNA2CCND3CDK6 | |
| SCHEMBL6086798 | 0.71 | IGF1R (0.50) | CDK4CDK2CCNA2CCND3CDK6 | |
| SCHEMBL6086207 | 0.70 | CDK4 (0.56) | CDK4CDK2CCNA2CCND3CDK6 | |
| SCHEMBL6088499 | 0.70 | CDK4 (0.75) | CDK4CDK2CCNA2CCND3CCND1 | |
| SCHEMBL6089773 | 0.70 | CDK4 (0.53) | CDK4CDK2CCNA2CCND3CDK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235815-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001038315-A1 | QUINAZOLINES AND THEIR USE FOR INHIBITING CYCLIN-DEPENDENT KINASE ENZYMES | WARNER-LAMBERT COMPANY (US) | 2001-05-31 | — | — | WO | disclosed |