Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 17/20 | 0.38 |
| ▸ | MAPT | P10636 | 11/20 | 0.38 |
| ▸ | MEN1 | O00255 | 10/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | HTT | P42858 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 8/20 | 0.38 |
| ▸ | GFER | P55789 | 4/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7521302 | 0.86 | GAA (0.50) | GAAMAPTMEN1KMT2AHSD17B10 | |
| SCHEMBL7525086 | 0.72 | NPC1 (0.50) | GAAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL7520249 | 0.72 | MEN1 (0.50) | GAAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL7524605 | 0.72 | RAB9A (0.51) | GAAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL7526790 | 0.70 | ALDH1A1 (0.40) | MAPTKMT2AALDH1A1HTTHPGD | |
| SCHEMBL7524552 | 0.70 | HTT (0.39) | GAAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL7522838 | 0.69 | STING1 (0.41) | KMT2AALDH1A1LMNA | |
| SCHEMBL7524654 | 0.68 | QPCT (0.40) | MAPTMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7523551 | 0.67 | RAB9A (0.53) | GAAMAPTMEN1KMT2AHSD17B10 | |
| SCHEMBL7524432 | 0.67 | SMN1; SMN2 (0.47) | GAAMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020058694-A1 | Ureido and thioureido derivatives of 4-amino-2(5H)-furanones and 4-amino-2(5H)-thiophenones as antitumor agents | ROCHE DIAGNOSTICS GMBH | 2002-05-16 | — | — | US | disclosed |
| US-6333346-B1 | AMINOFURANONEUREAS OR THIOUREAS 4-AMINO-2(5H)-THIOPHENONES AS ANTITUMOR AGENTS | ROCHE DIAGNOSTICS GMBH (DE) | 2001-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020058694-A1 | Ureido and thioureido derivatives of 4-amino-2(5H)-furanones and 4-amino-2(5H)-thiophenones as antitumor agents | UTS2R, SRD5A2, SRD5A1 | GAA 3891/4885MAPT 4634/4885MEN1 3390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.