Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3366209 | 0.89 | MTNR1A (0.59) | MTNR1AROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6652186 | 0.83 | MTNR1A (0.57) | MTNR1AROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2260257 | 0.82 | MTNR1A (0.57) | MTNR1AROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL98794 | 0.81 | MTNR1A (0.58) | MTNR1AROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7527438 | 0.81 | MTNR1A (0.58) | MTNR1AROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6650714 | 0.81 | MTNR1A (0.58) | MTNR1AROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL6649870 | 0.81 | MTNR1A (0.71) | MTNR1AROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9339000 | 0.80 | MTNR1A (0.57) | MTNR1AROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7523264 | 0.80 | MTNR1A (0.71) | MTNR1AROCK2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7519080 | 0.79 | MTNR1A (0.53) | MTNR1AROCK2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873993-B1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2002-02-20 | — | — | EP | disclosed |
| EP-0669331-B1 | Benzodioxane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-10-11 | — | — | EP | disclosed |
| US-5919814-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 1999-07-06 | — | — | US | disclosed |
| EP-0873993-A1 | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-10-28 | — | — | EP | disclosed |
| US-5500443-A | SCHIZOPHRENIA | ADIR ET COMPAGNIE (FR) | 1996-03-19 | — | — | US | disclosed |
| EP-0669331-A1 | Benzodioxane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-08-30 | — | — | EP | disclosed |