SCHEMBL7526436

SCHEMBL7526436

ICCC(OCc1ccccc1)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.51
CHRNA4 P43681 2/20 0.51
AOC3 Q16853 1/20 0.44
SLC6A2 P23975 3/20 0.44
SLC6A4 P31645 1/20 0.44
SLC6A3 Q01959 1/20 0.44
TSHR P16473 1/20 0.41
ALDH1A1 P00352 1/20 0.41
HPGD P15428 1/20 0.41
ALOX15 P16050 1/20 0.41
ALOX12 P18054 1/20 0.41
CASP1 P29466 1/20 0.41
HSD17B10 Q99714 1/20 0.41
TACR1 P25103 2/20 0.40
IDO1 P14902 2/20 0.39
SLC1A3 P43003 2/20 0.39
SLC1A2 P43004 2/20 0.39
SLC1A1 P43005 2/20 0.39
MEN1 O00255 1/20 0.39
CYP1A2 P05177 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3121962 0.93 CHRNB2 (0.49) CHRNB2CHRNA4AOC3SLC6A2SLC6A4
SCHEMBL19805891 0.83 CHRNB2 (0.54) CHRNB2CHRNA4AOC3SLC6A2SLC6A4
SCHEMBL16177726 0.79 CHRNB2 (0.46) CHRNB2CHRNA4AOC3SLC6A2SLC6A4
SCHEMBL4130181 0.79 CPA3 (0.47) CHRNB2CHRNA4SLC6A3SLC1A3SLC1A2
SCHEMBL14945152 0.78 CHRNB2 (0.53) CHRNB2CHRNA4AOC3SLC6A2SLC6A4
SCHEMBL5418286 0.78 CHRNB2 (0.53) CHRNB2CHRNA4AOC3SLC6A2SLC6A4
SCHEMBL9216785 0.78 CHRNB2 (0.77) CHRNB2CHRNA4AOC3SLC6A2SLC6A4
SCHEMBL16864526 0.78 CHRNB2 (0.53) CHRNB2CHRNA4AOC3SLC6A2SLC6A4
SCHEMBL28643037 0.77 TACR1 (0.56) CHRNB2CHRNA4AOC3SLC6A2SLC6A4
SCHEMBL25434926 0.76 SLC1A3 (0.46) CHRNB2CHRNA4AOC3TSHRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1353689-A Novel hydroxamic acid derivatives DAIICHI PREC KAGAKU (JP) 2002-06-12 CN disclosed
EP-1179529-A1 NOVEL HYDROXAMIC ACID DERIVATIVES Daiichi Fine Chemical Co., Ltd. (JP) 2002-02-13 EP disclosed
CN-1284060-A Novel metalloprotease inhibitors FUJI YAKUHIN KOGYO KK (JP) 2001-02-14 CN disclosed
EP-1038864-A1 NOVEL METALLOPROTEINASE INHIBITORS FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) 2000-09-27 EP disclosed