Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.31 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.31 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7522333 | 0.85 | MEN1 (0.38) | MEN1KMT2ANPC1PSMD14HSP90AA1 | |
| SCHEMBL7526690 | 0.83 | MEN1 (0.36) | MEN1KMT2ANPC1PSMD14HSP90AA1 | |
| SCHEMBL7520619 | 0.83 | MEN1 (0.36) | MEN1KMT2ANPC1PSMD14HSP90AA1 | |
| SCHEMBL7517206 | 0.81 | AR (0.37) | MEN1KMT2ANPC1PSMD14HSP90AA1 | |
| SCHEMBL7520384 | 0.80 | — | — | |
| SCHEMBL7520226 | 0.77 | MEN1 (0.36) | MEN1KMT2ANPC1PSMD14HSP90AA1 | |
| SCHEMBL7517845 | 0.74 | — | — | |
| SCHEMBL7517230 | 0.73 | ALOX15 (0.37) | MAPTMAPK1TDP1 | |
| SCHEMBL8443072 | 0.73 | ESR1 (0.40) | — | |
| SCHEMBL8579268 | 0.73 | HPN (0.40) | MEN1KMT2AGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |