Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.33 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7517206 | 0.92 | AR (0.37) | MEN1KMT2ANPC1ESR1ESR2 | |
| SCHEMBL7522333 | 0.89 | MEN1 (0.38) | MEN1KMT2ANPC1ESR1NR1H2 | |
| SCHEMBL7526901 | 0.83 | MEN1 (0.35) | MEN1KMT2ANPC1SOAT2ACAT1 | |
| SCHEMBL7522227 | 0.80 | ESR1 (0.33) | ESR1ESR2 | |
| SCHEMBL7520226 | 0.78 | MEN1 (0.36) | MEN1KMT2ANPC1SOAT2ACAT1 | |
| SCHEMBL7520619 | 0.78 | MEN1 (0.36) | MEN1KMT2ANPC1SOAT2ACAT1 | |
| SCHEMBL7523453 | 0.77 | ESR1 (0.36) | ESR1NR1H2NR1H3ESR2AR | |
| SCHEMBL7523695 | 0.76 | AR (0.43) | ESR1ESR2MAPTMAPK1NPSR1 | |
| SCHEMBL8579238 | 0.76 | MEN1 (0.39) | MEN1KMT2ANPC1ESR1ESR2 | |
| SCHEMBL7521992 | 0.74 | AR (0.36) | ESR1SOAT2ACAT1SOAT1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |