Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3742882 | 0.90 | HRH1 (0.43) | CHRNB2CHRNA4HTR1ASLC6A2CHRM3 | |
| SCHEMBL23674837 | 0.81 | MALT1 (0.31) | HTR1A | |
| SCHEMBL934085 | 0.78 | LRRK2 (0.35) | — | |
| SCHEMBL23674932 | 0.78 | LRRK2 (0.35) | — | |
| SCHEMBL23674966 | 0.77 | LOX (0.36) | — | |
| SCHEMBL7889387 | 0.76 | CHRNB2 (0.54) | CHRNB2CHRNA4HTR1ASLC6A2CHRM1 | |
| SCHEMBL4102786 | 0.76 | CHRNB2 (0.54) | CHRNB2CHRNA4HTR1ASLC6A2CHRM1 | |
| SCHEMBL2264859 | 0.71 | CHRNB2 (0.53) | CHRNB2CHRNA4HTR1ASLC6A2PRKCZ | |
| SCHEMBL3655274 | 0.71 | CHRNB2 (0.53) | CHRNB2CHRNA4HTR1ASLC6A2PRKCZ | |
| SCHEMBL31234233 | 0.71 | CHRNB2 (0.53) | CHRNB2CHRNA4HTR1ASLC6A2PRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212319-A2 | 3-PYRROLIDINYLOXY-3'-PYRIDYL ETHER COMPOUNDS USEFUL FOR CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | Abbott Laboratories (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019817-A3 | 3-PYRROLIDINYLOXY-3'-PYRIDYL ETHER COMPOUNDS USEFUL FOR CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2002-01-17 | — | — | WO | disclosed |
| WO-2001019817-A2 | 3-PYRROLIDINYLOXY-3'-PYRIDYL ETHER COMPOUNDS USEFUL FOR CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LABORATORIES (US) | 2001-03-22 | — | — | WO | disclosed |