Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.59 |
| ▸ | PPARG | P37231 | 7/20 | 0.59 |
| ▸ | PPARD | Q03181 | 7/20 | 0.59 |
| ▸ | PPARA | Q07869 | 7/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.59 |
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | TLR2 | O60603 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | FABP4 | P15090 | 2/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.59 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.59 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ESR1 | P03372 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | PDE4A | P27815 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28439674 | 0.89 | FFAR4 (0.65) | GPR84PPARGPPARDPPARAHDAC11 | |
| Dodecanoate SCHEMBL28392111 | 0.89 | GRM8 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Dodecanoate SCHEMBL28371028 | 0.89 | GRM8 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Palmitic Acid SCHEMBL4391708 | 0.89 | GRM8 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Stearic Acid SCHEMBL4391220 | 0.89 | GRM8 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Decanoic Acid SCHEMBL1045578 | 0.89 | GRM8 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Palmitic Acid SCHEMBL4391707 | 0.89 | GRM8 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Decanoic Acid SCHEMBL6751319 | 0.89 | GRM8 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Stearic Acid SCHEMBL4391222 | 0.89 | GRM8 (0.67) | GPR84PPARGPPARDPPARAHDAC11 | |
| Adipic Acid SCHEMBL6825345 | 0.89 | FFAR4 (0.65) | GPR84PPARGPPARDPPARAHDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130316957-A1 | SMOOTHENED POLYPEPTIDES AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV (US) | 2013-11-28 | — | — | US | disclosed |
| US-8546524-B2 | Smoothened polypeptides and methods of use | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2013-10-01 | — | — | US | disclosed |
| US-20120282196-A1 | SMOOTHENED POLYPEPTIDES AND METHODS OF USE | THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES (US) | 2012-11-08 | — | — | US | disclosed |
| US-8198402-B2 | Smoothened polypeptides and methods of use | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2012-06-12 | — | — | US | disclosed |
| EP-2431388-A1 | Smoothened polypeptides and methods of use | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services (US) | 2012-03-21 | — | — | EP | disclosed |
| US-20100093625-A1 | SMOOTHENED POLYPEPTIDES AND METHODS OF USE | THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICE (US) | 2010-04-15 | — | — | US | disclosed |
| EP-2078036-A2 | SMOOTHENED POLYPEPTIDES AND METHODS OF USE | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008070357-A9 | SMOOTHENED POLYPEPTIDES AND METHODS OF USE | US GOV HEALTH & HUMAN SERV (US) | 2008-08-14 | — | — | WO | disclosed |
| WO-2008070357-A2 | SMOOTHENED POLYPEPTIDES AND METHODS OF USE | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093625-A1 | SMOOTHENED POLYPEPTIDES AND METHODS OF USE | SMO, SHH, GLI1 | GPR84 145/4885PPARG 240/4885PPARD 413/4885 |
| US-20130316957-A1 | SMOOTHENED POLYPEPTIDES AND METHODS OF USE | SMO, SHH, GLI1 | GPR84 145/4885PPARG 240/4885PPARD 413/4885 |
| US-20120282196-A1 | SMOOTHENED POLYPEPTIDES AND METHODS OF USE | SMO, SHH, GLI1 | GPR84 145/4885PPARG 240/4885PPARD 413/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.