SCHEMBL7527375

SCHEMBL7527375

CN1C(=O)CC[C@]2(C)[C@H]3CC[C@]4(C)C(=O)CC[C@H]4[C@@H]3CC[C@@H]12

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HSD17B7 P56937 1/20 0.60
SRD5A1 P18405 1/20 0.59
SRD5A2 P31213 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7529348 1.00 HSD17B7 (0.60) HSD17B7SRD5A1SRD5A2
SCHEMBL13656757 1.00 HSD17B7 (0.60) HSD17B7SRD5A1SRD5A2
SCHEMBL7527383 1.00 HSD17B7 (0.60) HSD17B7SRD5A1SRD5A2
SCHEMBL14561091 0.84 SRD5A1 (0.56) HSD17B7SRD5A1SRD5A2
SCHEMBL7524799 0.84 HSD17B7 (0.57) HSD17B7SRD5A1SRD5A2
SCHEMBL5408042 0.84 SRD5A1 (0.56) HSD17B7SRD5A1SRD5A2
SCHEMBL5427981 0.84 SRD5A1 (0.56) SRD5A1SRD5A2
SCHEMBL7524800 0.84 HSD17B7 (0.57) HSD17B7SRD5A1SRD5A2
SCHEMBL5408037 0.84 SRD5A1 (0.56) HSD17B7SRD5A1SRD5A2
SCHEMBL10273977 0.84 CYP19A1 (0.53)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0880540-B1 17-BETA-CYCLOPROPYL(AMINO/OXY) 4-AZA STEROIDS AS ACTIVE INHIBITORS OF TESTOSTERONE 5-ALPHA-REDUCTASE AND C17-20-LYASE AVENTIS PHARMA INC (US) 2002-06-12 EP disclosed
US-6365597-B1 FOR THERAPY OF ANDROGEN AND ESTROGEN MEDIATED DISORDERS, INCLUDING BENIGN PROSTATIC HYPERPLASIA, ANDROGEN MEDIATED PROSTATE CANCER, ESTROGEN MEDIATED BREAST CANCER AND ACNE AVENTIS PHARMACEUTICALS INC. 2002-04-02 US disclosed
EP-0705273-B1 17-HALOGENO-4-AZAANDROSTENE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF RICHTER GEDEON VEGYESZET (HU) 2002-03-27 EP disclosed
EP-0705272-B1 NOVEL PROCESS FOR PREPARING 17 BETA-SUBSTITUTED 4-AZAANDROSTANE DERIVATIVES RICHTER GEDEON VEGYESZET (HU) 2002-03-27 EP disclosed
EP-0650495-B1 IMPROVED ANTIANDROGENS ENDORECHERCHE INC (CA) 2000-11-08 EP disclosed
US-6015806-A TOPICAL USE IN THE TREATMENT OF ANDROGEN-DEPENDENT DISEASES ASSOCIATED WITH THE SKIN. ENDORECHERCHE (CA) 2000-01-18 US disclosed
EP-0880540-A1 17-BETA-CYCLOPROPYL(AMINO/OXY) 4-AZA STEROIDS AS ACTIVE INHIBITORS OF TESTOSTERONE 5-ALPHA-REDUCTASE AND C17-20-LYASE HOECHST MARION ROUSSEL, INC. (US) 1998-12-02 EP disclosed
EP-0700291-B1 15-SUBSTITUTED 4-AZASTEROIDS MERCK & CO INC (US) 1998-09-16 EP disclosed
WO-1997030069-A1 17-BETA-CYCLOPROPYL(AMINO/OXY) 4-AZA STEROIDS AS ACTIVE INHIBITORS OF TESTOSTERONE 5-ALPHA-REDUCTASE AND C17-20-LYASE HOECHST MARION ROUSSEL, INC. (US) 1997-08-21 WO disclosed
US-5583138-A REDUCTASE INHIBITOR; SKIN DISORDERS RICHTER GEDEON VEGYESZETI GYAR RT. (HU) 1996-12-10 US disclosed
EP-0641211-A1 INHIBITORS OF TESTOSTERONE 5$g(a)-REDUCTASE ACTIVITY ENDORECHERCHE INC. (CA) 1995-03-08 EP disclosed
WO-1995000532-A1 17-HALOGENO-4-AZAANDROSTENE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF Richter Gedeon Vegyészeti Gyár Rt. (HU) 1995-01-05 WO disclosed
WO-1995000531-A1 NOVEL PROCESS FOR PREPARING 17β-SUBSTITUTED 4-AZAANDROSTANE DERIVATIVES Richter Gedeon Vegyészeti Gyár Rt. (HU) 1995-01-05 WO disclosed
WO-1994026767-A1 IMPROVED ANTIANDROGENS ENDORECHERCHE INC. (CA) 1994-11-24 WO disclosed
US-5359071-A Selective antagonist of testosterone 5-alpha-reductase 1 MERCK & CO., INC. (US) 1994-10-25 US disclosed
WO-1993023053-A1 INHIBITORS OF TESTOSTERONE 5α-REDUCTASE ACTIVITY ENDORECHERCHE INC. (CA) 1993-11-25 WO disclosed
US-5155107-A Inhibiting androgen action, anticarcinogenic agents, treating skin disorders, baldness FARMITALIA CARLO ERBA (IT) 1992-10-13 US disclosed
EP-0468012-A1 17-g(b)-SUBSTITUTED-4-AZA-5-g(a)-ANDROSTAN-3-ONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. ERBA CARLO SPA (IT) 1992-01-29 EP disclosed
WO-1991012261-A1 17β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION FARMITALIA CARLO ERBA S.R.L. (IT) 1991-08-22 WO disclosed
US-4377584-A 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors MERCK & CO., INC. (US) 1983-03-22 US disclosed