Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | ABAT | P80404 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ECE1 | P42892 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11655732 | 0.83 | CRHBP (0.53) | MMECRHBPCRHR2ABATACE | |
| SCHEMBL27650909 | 0.81 | MME (0.44) | MMECRHBPCRHR2ABATACE | |
| SCHEMBL11860604 | 0.78 | MME (0.44) | MMECRHBPCRHR2ABATACE | |
| SCHEMBL4784860 | 0.76 | POLB (0.50) | ALDH1A1HSD17B10MEN1MAPTKMT2A | |
| SCHEMBL27471886 | 0.76 | KMT2A (0.39) | CRHBPCRHR2HPGDMAPK1MEN1 | |
| SCHEMBL8879718 | 0.74 | MME (0.45) | MMECRHBPCRHR2ABATACE | |
| SCHEMBL28387237 | 0.74 | CYP2D6 (0.44) | ALDH1A1MAPK1KMT2A | |
| SCHEMBL28387238 | 0.74 | CYP2D6 (0.44) | ALDH1A1MAPK1KMT2A | |
| SCHEMBL11629718 | 0.74 | MME (0.54) | MMEABATACEALDH1A1HPGD | |
| SCHEMBL30221846 | 0.73 | PPARG (0.47) | MMECRHBPCRHR2ACEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430014-A1 | ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132601-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2010-11-18 | — | — | WO | disclosed |