Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | NAMPT | P43490 | 8/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.53 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17887994 | 0.87 | SMN1; SMN2 (0.77) | SMN1; SMN2HTTRAB9ANPC1ALDH1A1 | |
| SCHEMBL13652523 | 0.85 | RAB9A (0.58) | SMN1; SMN2HTTRAB9ANPC1ALDH1A1 | |
| SCHEMBL5507897 | 0.84 | SMN1; SMN2 (0.61) | SMN1; SMN2HTTALDH1A1NFKB1KCNH2 | |
| SCHEMBL24648929 | 0.83 | SMN1; SMN2 (0.69) | SMN1; SMN2HTTRAB9ANPC1ALDH1A1 | |
| SCHEMBL5508324 | 0.82 | ALDH1A1 (0.70) | SMN1; SMN2HTTALDH1A1NFKB1KCNH2 | |
| SCHEMBL11196763 | 0.81 | ALDH1A1 (0.64) | SMN1; SMN2HTTALDH1A1NFKB1KCNH2 | |
| SCHEMBL14297350 | 0.80 | NPC1 (0.69) | SMN1; SMN2HTTRAB9ANPC1ALDH1A1 | |
| SCHEMBL6570929 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2HTTRAB9ANPC1ALDH1A1 | |
| SCHEMBL17301589 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2HTTRAB9ANPC1NAMPT | |
| SCHEMBL15087813 | 0.79 | NAMPT (0.60) | SMN1; SMN2HTTALDH1A1NFKB1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1079820-A1 | BENZAMIDE THERAPEUTICS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE | CENTAUR PHARMACEUTICALS, INC. (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999059569-A1 | BENZAMIDE THERAPEUTICS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE | CENTAUR PHARMACEUTICALS, INC. (US) | 1999-11-25 | — | — | WO | disclosed |