Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | LPO | P22079 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27599189 | 0.98 | TSHR (0.34) | TSHRALDH1A1POLBSMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL27665005 | 0.98 | TSHR (0.34) | TSHRALDH1A1POLBSMN1; SMN2HTT | |
| SCHEMBL30305960 | 0.70 | TSHR (0.41) | TSHRALDH1A1POLBSMN1; SMN2HTT | |
| SCHEMBL28187319 | 0.67 | ALDH1A1 (0.41) | TSHRALDH1A1POLBSMN1; SMN2HTT | |
| SCHEMBL4553516 | 0.66 | ALDH1A1 (0.37) | ALDH1A1POLBSMN1; SMN2BCHELMNA | |
| SCHEMBL28332421 | 0.65 | TSHR (0.39) | TSHRALDH1A1POLBSMN1; SMN2HTT | |
| SCHEMBL4771331 | 0.65 | TSHR (0.35) | TSHRALDH1A1POLBSMN1; SMN2HTT | |
| SCHEMBL25759298 | 0.64 | ALDH1A1 (0.38) | TSHRALDH1A1POLBSMN1; SMN2HTT | |
| Hydrochloric Acid SCHEMBL4774116 | 0.64 | TSHR (0.34) | TSHRALDH1A1POLBSMN1; SMN2HTT | |
| SCHEMBL6192241 | 0.63 | TSHR (0.33) | TSHRALDH1A1POLBSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109354584-A | The method of one pot process 2- (4- hydroxy phenyl) -4- methyl-1,3-thiazole-5-carboxylic acid ethyl ester | 湖北理工学院 | 2019-02-19 | — | — | CN | claimed |
| CN-104220069-B | Trpm8 antagonists | 多姆皮制药公司 | 2018-10-02 | — | — | CN | claimed |
| CN-101921243-B | Method for preparing 2-(3-formacyl-4-isobutoxyphenyl)-4-methyl-1,3 thiazole-5-carboxylic acid ethyl ester | QINGDAO HUANGHAI PHARMACEUTICAL CO LTD | 2012-10-10 | — | — | CN | claimed |
| CN-102239160-A | Substituted (pyridyl) -azinylamine derivatives as fungicides | BAYER CROPSCIENCE SA | 2011-11-09 | — | — | CN | claimed |
| CN-101921243-A | Method for preparing 2-(3-formacyl-4-isobutoxyphenyl)-4-methyl-1,3 thiazole-5-carboxylic acid ethyl ester | QINGDAO HUANGHAI PHARMACEUTICAL CO LTD | 2010-12-22 | — | — | CN | claimed |
| CN-101391988-B | Method for preparing 2- (4-hydroxyphenyl) -4-methyl-1, 3-thiazole-5-carboxylic acid ethyl ester by one-pot method | NANJING UNIVERSITY OF TECHNOLOGY | 2010-09-08 | — | — | CN | claimed |
| CN-101391988-A | Method for preparing 2- (4-hydroxyphenyl) -4-methyl-1, 3-thiazole-5-carboxylic acid ethyl ester by one-pot method | NANJING UNIVERSITY OF TECHNOLOGY (CN) | 2009-03-25 | — | — | CN | claimed |
| CN-101171250-A | Tricyclic derivatives of azetidine and pyrrole having antibacterial activity | ASTRAZENECA AB (SE) | 2008-04-30 | — | — | CN | claimed |
| CN-1729177-A | Novel uracils having herbicidal activity | ISAGRO RICERCA SRL (IT) | 2006-02-01 | — | — | CN | claimed |
| CN-116848107-A | Compounds and their use as PDE4 activators | 米罗尼德有限公司 | 2023-10-03 | — | — | CN | disclosed |
| CN-113396145-A | PFKFB3 inhibitors and uses thereof | 盖罗发现有限责任公司 | 2021-09-14 | — | — | CN | disclosed |
| CN-107266419-B | Certain amino-pyridazines, compositions thereof, and methods of use thereof | 赛特凯恩蒂克公司 | 2021-05-11 | — | — | CN | disclosed |
| CN-111601810-A | Inhibitors of indoleamine 2, 3-dioxygenase and/or tryptophan 2, 3-dioxygenase | 爱杜西亚药品有限公司 | 2020-08-28 | — | — | CN | disclosed |
| CN-110997682-A | Inhibitors of indoleamine 2, 3-dioxygenase and/or tryptophan 2, 3-dioxygenase | 爱杜西亚药品有限公司 | 2020-04-10 | — | — | CN | disclosed |
| CN-1500080-A | Fused heterocyclic compounds | ����ҩƷ��ҵ��ʽ���� | 2004-05-26 | — | — | CN | disclosed |
| CN-1437587-A | Benzoxazepinones and their use as squalene synthetase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-08-20 | — | — | CN | disclosed |
| CN-1426303-A | Thiazole, imidazole and oxazole compounds and treatment of diseases associated with protein aging | ALTEON INC (US) | 2003-06-25 | — | — | CN | disclosed |
| CN-1402716-A | Substituted oxazole and thiazole derivatives as HPPAR alpha activators | GLAXO GROUP LTD (GB) | 2003-03-12 | — | — | CN | disclosed |
| CN-1358179-A | Thiazole and oxazole derivatives and their pharmaceutical use | GLAXO GROUP LTD (GB) | 2002-07-10 | — | — | CN | disclosed |
| WO-2002015662-A2 | QUINUCLIDINE-SUBSTITUTED HETEROARYL MOIETIES FOR TREATMENT OF DISEASE (NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-02-28 | — | — | WO | disclosed |