Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | IDH1 | O75874 | 15/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | CDK1 | P06493 | 1/20 | 0.64 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.64 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.64 |
| ▸ | CDK2 | P24941 | 1/20 | 0.64 |
| ▸ | CDK7 | P50613 | 1/20 | 0.64 |
| ▸ | CCNH | P51946 | 1/20 | 0.64 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15647028 | 0.84 | IDH1 (0.66) | IDH1CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL20725320 | 0.83 | IDH1 (0.90) | IDH1 | |
| SCHEMBL9222670 | 0.82 | ALDH1A1 (0.69) | ALDH1A1GAATSHRLMNAHPGD | |
| SCHEMBL15702757 | 0.82 | IDH1 (1.00) | IDH1 | |
| SCHEMBL8752501 | 0.81 | ALDH1A1 (1.00) | ALDH1A1GAATSHRIDH1LMNA | |
| SCHEMBL10574491 | 0.81 | APP (0.57) | ALDH1A1GAATSHRIDH1LMNA | |
| SCHEMBL15702381 | 0.80 | IDH1 (1.00) | IDH1 | |
| SCHEMBL28732270 | 0.80 | IDH1 (0.60) | ALDH1A1IDH1CDK1CCNB1CCNA2 | |
| SCHEMBL7580547 | 0.80 | IDH1 (0.71) | IDH1SMN1; SMN2CDK1CCNB1CCNA2 | |
| SCHEMBL15702401 | 0.80 | IDH1 (1.00) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020183393-A1 | Inhibitors of Rho C | ICONIX PHARMACEUTICALS INC. | 2002-12-05 | — | — | US | disclosed |
| WO-2002022565-A1 | INHIBITORS OF RHO C | ICONIX PHARMACEUTICALS, INC. (US) | 2002-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183393-A1 | Inhibitors of Rho C | RHOC, ROCK1, RHOA | ALDH1A1 3776/4885GAA 4439/4885TSHR 488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.