Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.50 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.50 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7378848 | 0.78 | SLC6A4 (0.46) | GRIN1GRIN2ASLC6A4OPRK1GRIN2D | |
| SCHEMBL7546727 | 0.78 | SLC6A4 (0.46) | GRIN1GRIN2ASLC6A4OPRK1GRIN2D | |
| Hydrochloric Acid SCHEMBL7949501 | 0.77 | SLC6A4 (0.45) | GRIN1GRIN2ASLC6A4OPRK1GRIN2D | |
| SCHEMBL9545809 | 0.72 | SLC6A4 (0.43) | GRIN1GRIN2ASLC6A4OPRK1GRIN2D | |
| SCHEMBL7948379 | 0.72 | SLC6A4 (0.43) | GRIN1GRIN2ASLC6A4OPRK1GRIN2D | |
| SCHEMBL31115767 | 0.71 | GRIN1 (0.91) | GRIN1GRIN2ASLC6A4OPRK1GRIN2D | |
| Hydrochloric Acid SCHEMBL31115766 | 0.70 | GRIN1 (0.88) | GRIN1GRIN2ASLC6A4OPRK1GRIN2D | |
| Hydrochloric Acid SCHEMBL31115764 | 0.70 | GRIN1 (0.88) | GRIN1GRIN2ASLC6A4OPRK1GRIN2D | |
| SCHEMBL8260842 | 0.69 | KDM1A (0.53) | KDM1AMEN1KMT2ASIGMAR1 | |
| SCHEMBL10483582 | 0.68 | KDM1A (0.51) | KDM1AMEN1KMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0947499-B1 | Process for the preparation of racemic sertraline | CATALYS (FR) | 2002-02-20 | — | — | EP | disclosed |
| EP-0947499-A2 | Process for the preparation of racemic sertraline | Catalys (FR) | 1999-10-06 | — | — | EP | disclosed |