Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 7/20 | 0.75 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.75 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.75 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.75 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.56 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.53 |
| ▸ | OR51E2 | Q9H255 | 2/20 | 0.53 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | KDM5C | P41229 | 2/20 | 0.53 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.53 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL7752977 | 0.96 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL28729193 | 0.96 | LMNA (0.82) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL29055436 | 0.91 | LMNA (0.90) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL8785695 | 0.91 | LMNA (0.90) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL8834515 | 0.91 | LMNA (0.90) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL9655214 | 0.91 | LMNA (0.90) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL2715362 | 0.91 | LMNA (0.90) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL5712999 | 0.91 | LMNA (0.90) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL22217475 | 0.91 | LMNA (0.90) | LMNAEGLN1ALKBH5SUCNR1GABRR1 | |
| Succinic Acid SCHEMBL610172 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618843-B1 | PHOSPHONIC ACID BASED ION EXCHANGE RESINS | ARCH DEV CORP (US) | 2002-03-13 | — | — | EP | disclosed |
| US-5539003-A | CROSSLINKED POLYMERS OF ACRYLAMIDE OR STYRENE WITH ACRYLIC ACID, ESTERS OR ACRYLONITRILE FOR DEMETALLIZATION OF ACID SOLUTIONS | UNIVERSITY OF TENNESSEE RESEARCH CORPORATION | 1996-07-23 | — | — | US | disclosed |
| US-5449462-A | Vinylidenediphosphonic acid | ARCH DEVELOPMENT CORP. (US) | 1995-09-12 | — | — | US | disclosed |
| EP-0618843-A4 | PHOSPHONIC ACID BASED ION EXCHANGE RESINS. | ARCH DEV CORP (US) | 1995-04-12 | — | — | EP | disclosed |
| EP-0618843-A1 | PHOSPHONIC ACID BASED ION EXCHANGE RESINS | ARCH DEVELOPMENT CORPORATION (US) | 1994-10-12 | — | — | EP | disclosed |
| US-5281631-A | Comprising vinylidenediphosphonic acid, acrylamide or styrene, acrylonitrile, methyl acrylate or methacrylate, divinylic acid, and trivinylic crosslinking agents | ARCH DEVELOPMENT CORP. (US) | 1994-01-25 | — | — | US | disclosed |
| WO-1993012882-A1 | PHOSPHONIC ACID BASED ION EXCHANGE RESINS | ARCH DEVELOPMENT CORP. (US) | 1993-07-08 | — | — | WO | disclosed |