SCHEMBL7528666

SCHEMBL7528666

CC(=O)N(c1ccc(C(=O)O)cc1)c1ccc(C(=O)Nc2ccc(C=Cc3ccccc3)cc2C(=O)O)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SNCA P37840 3/20 0.47
SERPINE1 P05121 4/20 0.45
MEN1 O00255 3/20 0.44
KMT2A Q03164 3/20 0.44
MAPT P10636 3/20 0.44
TDP1 Q9NUW8 2/20 0.44
LTC4S Q16873 1/20 0.44
ALDH1A1 P00352 1/20 0.44
HTT P42858 1/20 0.44
GFER P55789 1/20 0.44
PKM P14618 1/20 0.44
GRIK1 P39086 1/20 0.44
PTPN1 P18031 2/20 0.43
HNF4A P41235 1/20 0.43
HDAC1 Q13547 1/20 0.43
DHODH Q02127 1/20 0.41
SRD5A1 P18405 1/20 0.41
SRD5A2 P31213 1/20 0.41
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7528656 1.00 SNCA (0.47) SNCASERPINE1MEN1KMT2AMAPT
SCHEMBL7530317 0.92 KCNK2 (0.47) SNCASERPINE1MEN1KMT2AMAPT
SCHEMBL7530325 0.92 KCNK2 (0.47) SNCASERPINE1MEN1KMT2AMAPT
SCHEMBL7527364 0.90 MAPT (0.57) SNCAMEN1KMT2AMAPTTDP1
SCHEMBL7527352 0.90 MAPT (0.57) SNCAMEN1KMT2AMAPTTDP1
SCHEMBL7526855 0.89 SNCA (0.47) SNCASERPINE1MEN1KMT2AMAPT
SCHEMBL7526860 0.89 SNCA (0.47) SNCASERPINE1MEN1KMT2AMAPT
SCHEMBL7646355 0.87 ALDH1A1 (0.47) SNCAKMT2AMAPTLTC4SALDH1A1
SCHEMBL7528663 0.86 SNCA (0.49) SNCASERPINE1MEN1KMT2AMAPT
SCHEMBL7534111 0.84 MAPT (0.55) SNCAMEN1KMT2AMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020032218-A1 Substituted stilbenes as glucose uptake enhancers TELIK, INC. 2002-03-14 US claimed
US-6479548-B2 P-(BENZOYLAMINO)STILBENE DERIVATIVES TELIK, INC. 2002-11-12 US disclosed
US-20020032218-A1 Substituted stilbenes as glucose uptake enhancers TELIK, INC. 2002-03-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020032218-A1 Substituted stilbenes as glucose uptake enhancers SLC2A1, SLC2A8, SLC2A2 SNCA 3814/4885SERPINE1 1552/4885MEN1 2354/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.