SCHEMBL7528775

SCHEMBL7528775

COC(=O)c1ccc(C(=O)N(C)c2ccc(C(=O)Nc3ccc(/C=C/c4ccccc4)c(C(=O)O)c3)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 1/20 0.46
KMT2A Q03164 4/20 0.45
LMNA P02545 4/20 0.45
MEN1 O00255 3/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
KDM4E B2RXH2 2/20 0.45
SNCA P37840 2/20 0.45
MAPT P10636 2/20 0.45
ALDH1A1 P00352 3/20 0.45
TSHR P16473 1/20 0.45
HSD17B10 Q99714 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
RAB9A P51151 4/20 0.45
NR1H4 Q96RI1 1/20 0.43
KCNK3 O14649 1/20 0.43
NPC1 O15118 3/20 0.43
HTT P42858 3/20 0.42
APP P05067 1/20 0.42
ITGB3 P05106 1/20 0.42
ITGAV P06756 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7529029 0.93 SNCA (0.46) PTPN1KMT2AKDM4ESNCAMAPT
SCHEMBL7528772 0.88 PTPN1 (0.46) PTPN1KMT2ALMNAMEN1SMN1; SMN2
SCHEMBL7528779 0.88 PTPN1 (0.46) PTPN1KMT2ALMNAMEN1SMN1; SMN2
SCHEMBL7646488 0.83 KMT2A (0.55) PTPN1KMT2ALMNAMEN1SMN1; SMN2
SCHEMBL7646483 0.83 KMT2A (0.55) PTPN1KMT2ALMNAMEN1SMN1; SMN2
SCHEMBL7526766 0.83 KMT2A (0.55) PTPN1KMT2ALMNAMEN1SMN1; SMN2
SCHEMBL7529010 0.83 KMT2A (0.60) PTPN1KMT2ALMNAMEN1SMN1; SMN2
SCHEMBL7529022 0.83 KMT2A (0.60) PTPN1KMT2ALMNAMEN1SMN1; SMN2
SCHEMBL7528948 0.82 KMT2A (0.57) PTPN1KMT2AMEN1SMN1; SMN2SNCA
SCHEMBL7528955 0.82 KMT2A (0.57) PTPN1KMT2AMEN1SMN1; SMN2SNCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020032218-A1 Substituted stilbenes as glucose uptake enhancers TELIK, INC. 2002-03-14 US claimed
US-6479548-B2 P-(BENZOYLAMINO)STILBENE DERIVATIVES TELIK, INC. 2002-11-12 US disclosed
US-20020032218-A1 Substituted stilbenes as glucose uptake enhancers TELIK, INC. 2002-03-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020032218-A1 Substituted stilbenes as glucose uptake enhancers SLC2A1, SLC2A8, SLC2A2 PTPN1 1380/4885KMT2A 3788/4885LMNA 4273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.