Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | STK39 | Q9UEW8 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7530844 | 0.91 | KMT2A (0.40) | ESR1ESR2MEN1KMT2AMAPT | |
| SCHEMBL7528055 | 0.88 | MEN1 (0.40) | ESR1ESR2MEN1KMT2AMAPT | |
| SCHEMBL7523887 | 0.87 | ESR1 (0.44) | ESR1ESR2KDM4ENPC1ALDH1A1 | |
| SCHEMBL7526863 | 0.87 | ESR1 (0.38) | ESR1ESR2MEN1KMT2AMAPT | |
| SCHEMBL7528005 | 0.85 | MEN1 (0.42) | ESR1ESR2MEN1KMT2AMAPT | |
| SCHEMBL8966375 | 0.81 | ESR1 (0.46) | ESR1ESR2MEN1KMT2AMAPT | |
| SCHEMBL7527272 | 0.78 | ESR1 (0.59) | ESR1ESR2ACHE | |
| SCHEMBL7535540 | 0.77 | ESR1 (0.47) | ESR1ESR2MEN1KMT2AMAPT | |
| SCHEMBL7532969 | 0.77 | MEN1 (0.40) | ESR1ESR2MEN1KMT2AMAPT | |
| SCHEMBL7527845 | 0.75 | ESR1 (0.45) | ESR1ESR2GAAKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832881-B1 | Benzofluorene compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2002-04-03 | — | — | EP | disclosed |
| EP-0832881-A2 | Benzofluorene compounds, intermediates, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |