Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358464 | 0.93 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL5358412 | 0.92 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL5362091 | 0.90 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL5370943 | 0.90 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL5361988 | 0.89 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL5362615 | 0.89 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL5362716 | 0.88 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL5354967 | 0.85 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL5370946 | 0.84 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DTSHR | |
| SCHEMBL7367596 | 0.83 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020111495-A1 | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes | PFIZER INC. | 2002-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020111495-A1 | Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes | NOX3, NOX1, NOX4 | PDE4A 4/4885PDE4B 5/4885PDE4C 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.