Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.34 |
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.34 |
| ▸ | DRD1 | P21728 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.34 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419935 | 0.95 | DRD1 (0.42) | DRD1HTR2ACYP2D6NR3C1GRIN2D | |
| SCHEMBL989840 | 0.87 | DRD1 (0.37) | DRD1HTR2ANR3C1OPRM1DRD2 | |
| SCHEMBL7529635 | 0.83 | ACHE (0.35) | MAPTSMN1; SMN2OPRM1OPRD1OPRK1 | |
| SCHEMBL8027935 | 0.82 | ESR2 (0.42) | — | |
| SCHEMBL8747213 | 0.81 | DRD1 (0.49) | DRD1HTR2ADRD2OPRD1OPRK1 | |
| SCHEMBL7474566 | 0.81 | SIGMAR1 (0.44) | DRD1HTR2ACYP2D6GRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL8747194 | 0.80 | DRD1 (0.50) | DRD1HTR2ADRD2OPRD1OPRK1 | |
| SCHEMBL7419696 | 0.76 | DRD1 (0.39) | DRD1DRD2 | |
| SCHEMBL8747078 | 0.76 | DRD1 (0.44) | DRD1HTR2ADRD2 | |
| Bromide SCHEMBL8747367 | 0.75 | DRD1 (0.43) | DRD1HTR2ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046713-C | Tetrahydroisoquinoline compounds, pharmaceutical compositions containing them, and their preparation and use | KNORR CO LTD (GB) | 1999-11-24 | — | — | CN | disclosed |
| US-5807868-A | ANALGESICS; PSYCHOLOGICAL DISORDES; PARKINSON*S DIESASE;COGNITION ACTIVATORS; DRUG DEPENDENCE; DYSKINESIA | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-09-15 | — | — | US | disclosed |
| US-5804586-A | ANALGESICS, PSYCHOLOGICAL DISORDERS | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-09-08 | — | — | US | disclosed |
| EP-0707570-B1 | ISOQUINOLINE DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1998-05-06 | — | — | EP | disclosed |
| CN-1128992-A | Therapeutic agents | KNORR CO LTD (DE) | 1996-08-14 | — | — | CN | disclosed |
| EP-0707570-A1 | ISOQUINOLINE DERIVATIVES AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995000489-A1 | ISOQUINOLINE DERIVATIVES AS THERAPEUTIC AGENTS | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |