Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR2C | P28335 | 3/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1427141 | 0.75 | MAPK1 (0.50) | SIGMAR1SLC18A3 | |
| SCHEMBL2561586 | 0.71 | HTR2A (0.61) | HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL1457116 | 0.71 | HTR2A (0.64) | HTR2AHTR2CHTR7HTR6 | |
| SCHEMBL19124208 | 0.70 | SLC18A3 (0.47) | SIGMAR1SLC18A3 | |
| SCHEMBL19130583 | 0.70 | SLC18A3 (0.47) | SIGMAR1SLC18A3 | |
| SCHEMBL5871000 | 0.70 | DRD3 (0.47) | HTR2AHTR2CHTR2BHTR7HTR6 | |
| SCHEMBL5871132 | 0.70 | SIGMAR1 (0.61) | SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL5871816 | 0.68 | DRD2 (0.47) | SIGMAR1HTR2AHTR2CHTR2B | |
| SCHEMBL5871308 | 0.68 | HTR2A (0.42) | SIGMAR1HTR2AHTR2CHTR2BHTR7 | |
| SCHEMBL3812419 | 0.68 | SIGMAR1 (1.00) | SIGMAR1HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002030422-A1 | USE OF DEFINED SUBSTANCES THAT BIND TO THE SIGMA RECEPTOR FOR COMBATING SARCOMA AND CARCINOMA | MERCK PATENT GMBH (DE) | 2002-04-18 | — | — | WO | claimed |
| WO-2002030422-A1 | USE OF DEFINED SUBSTANCES THAT BIND TO THE SIGMA RECEPTOR FOR COMBATING SARCOMA AND CARCINOMA | MERCK PATENT GMBH (DE) | 2002-04-18 | — | — | WO | disclosed |
| WO-2002030422-A1 | USE OF DEFINED SUBSTANCES THAT BIND TO THE SIGMA RECEPTOR FOR COMBATING SARCOMA AND CARCINOMA | MERCK PATENT GMBH (DE) | 2002-04-18 | — | — | WO | disclosed |