Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Glutathione Ethyl Ester. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.54 |
| ▸ | GLO1 | Q04760 | 3/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 5/20 | 0.38 |
| ▸ | CASR | P41180 | 4/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutathione Ethyl Ester SCHEMBL7523000 | 1.00 | PTGS1 (0.54) | PTGS1GSTK1GLO1NOD1CASR | |
| Glutathione Ethyl Ester SCHEMBL7526098 | 0.89 | PTGS1 (0.65) | PTGS1GSTK1GLO1NOD1FNTA | |
| Glutathione Ethyl Ester SCHEMBL7527153 | 0.89 | PTGS1 (0.65) | PTGS1GSTK1GLO1NOD1FNTA | |
| Glutathione Ethyl Ester SCHEMBL7530375 | 0.89 | PTGS1 (0.65) | PTGS1GSTK1GLO1NOD1FNTA | |
| Glutathione Ethyl Ester SCHEMBL7527777 | 0.89 | PTGS1 (0.65) | PTGS1GSTK1GLO1NOD1FNTA | |
| Glutathione Ethyl Ester SCHEMBL7530345 | 0.87 | PTGS1 (0.71) | PTGS1GSTK1GLO1NOD1 | |
| Glutathione Ethyl Ester SCHEMBL680361 | 0.87 | PTGS1 (0.71) | PTGS1GSTK1GLO1NOD1 | |
| Glutathione Ethyl Ester SCHEMBL9817298 | 0.87 | PTGS1 (0.71) | PTGS1GSTK1GLO1NOD1 | |
| Glutathione Ethyl Ester SCHEMBL8749892 | 0.86 | PTGS1 (0.70) | PTGS1GSTK1GLO1NOD1 | |
| SCHEMBL19293518 | 0.80 | PTGS1 (0.59) | PTGS1GSTK1GLO1NOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0806432-B1 | Glutathione monoester sulfonate | KYOWA HAKKO KOGYO KK (JP) | 2002-03-20 | — | — | EP | disclosed |
| US-5756823-A | Glutathione monoester sulfonate | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1998-05-26 | — | — | US | disclosed |
| EP-0806432-A1 | Glutathione monoester sulfonate | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-11-12 | — | — | EP | disclosed |