Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.35 |
| ▸ | KDM5A | P29375 | 5/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
| ▸ | KDM4A | O75164 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL479838 | 1.00 | MRGPRX4 (0.38) | MRGPRX4FFAR1KDM5AKDM4CKDM5B | |
| SCHEMBL754430 | 0.92 | MRGPRX4 (0.33) | MRGPRX4FFAR1KDM5AKDM5BGABRA1 | |
| SCHEMBL479696 | 0.92 | MRGPRX4 (0.33) | MRGPRX4FFAR1KDM5AKDM5BGABRA1 | |
| SCHEMBL15789687 | 0.91 | FFAR1 (0.35) | MRGPRX4FFAR1KDM5AKDM4CKDM5B | |
| SCHEMBL15789765 | 0.89 | FFAR1 (0.34) | MRGPRX4FFAR1KDM5AKDM4CKDM5B | |
| SCHEMBL480021 | 0.88 | MRGPRX4 (0.38) | MRGPRX4FFAR1KDM5AKDM4CKDM5B | |
| SCHEMBL752266 | 0.88 | MRGPRX4 (0.38) | MRGPRX4FFAR1KDM5AKDM4CKDM5B | |
| SCHEMBL753249 | 0.86 | MRGPRX4 (0.41) | MRGPRX4FFAR1KDM5AKDM4CKDM5B | |
| SCHEMBL734262 | 0.86 | MRGPRX4 (0.41) | MRGPRX4FFAR1KDM5AKDM4CKDM5B | |
| SCHEMBL15789781 | 0.84 | FFAR1 (0.34) | MRGPRX4FFAR1KDM5AKDM4CKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138189-B2 | Substituted benzene compounds as modulators of the glucocorticoid receptor | HOFFMAN-LA ROCHE INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-8138189-B2 | Substituted benzene compounds as modulators of the glucocorticoid receptor | HOFFMAN-LA ROCHE INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20100249139-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | HOFFMANN-LA ROCHE, INC. | 2010-09-30 | — | — | US | disclosed |
| US-20100249139-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | HOFFMANN-LA ROCHE, INC. | 2010-09-30 | — | — | US | disclosed |
| WO-2010108902-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249139-A1 | 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | NR3C1, NR3C2, CRHR1 | MRGPRX4 284/4885FFAR1 45/4885KDM5A 2193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.