Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.55 |
| ▸ | OGA | O60502 | 1/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.50 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.50 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7237136 | 1.00 | CHRNB2 (0.55) | CHRNB2CHRNA4OGACHRNB4CHRNA3 | |
| SCHEMBL6311327 | 0.92 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL24521960 | 0.92 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL6306245 | 0.92 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL1936160 | 0.85 | CHRM2 (0.62) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL16845110 | 0.84 | CHRNB2 (0.67) | CHRNB2CHRNA4OGACHRNB4CHRNA3 | |
| SCHEMBL31276985 | 0.84 | CHRNB2 (0.67) | CHRNB2CHRNA4OGACHRNB4CHRNA3 | |
| SCHEMBL12819481 | 0.83 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL20147421 | 0.83 | OGA (0.57) | CHRNB2CHRNA4OGACHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL16823600 | 0.83 | CHRNB2 (0.65) | CHRNB2CHRNA4OGACHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441006-B2 | NERVOUS SYSTEM DISORDERS | TARGACEPT, INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1185513-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000071520-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2000-11-30 | — | — | WO | disclosed |